Liberation from stigma is the first step in freeing from addiction. Historical and clinical scientific considerations of alcohol, cocaine and stimulants are reviewed. As an example of stigma, E.O'Neill's master-piece playwright “Long Day's Journey Into Night” is given. Primary, secondary and terciary prevention of addiction with evidence based pharmacological treatment of alcohol, cocaine and other stimulants and opiates addiction is discussed. Especial attention is given to simultaneous and combined pharmacotherapy of addiction and co-occurring disorders. The new Portugal law which decriminalizes addiction and captures liberation of stigma is reviewed. Ending with the movie “Flight” which embraces the concept of freedom from addiction and stigma.