Table of Contents

About the Santa Fe Institute — Santa Fe Institute Editorial Board August 1989 — Santa Fe Institute Studies in the Sciences of Complexity — Preface: Applied Molecular Evolution on Rugged Fitness Landscapes — Rugged Landscapes and Evolution — Optimization on Rugged Landscapes — A Spin-Glass Model of Evolution — What Can Physics Do For Biology? — Optimization of RNA Structure and Properties — Somatic Evolution of Antibody Variable-Region Genes & Maturation of the Immune Response — Affinity Maturation: A Retrospective View — Maturation through Hypermutation and Selection — Affinity Maturation on Rugged Landscapes — Maturation of the Humoral Immune Response: A Neo-Darwinian Process? — The NK Model of Rugged Fitness Landscapes and Its Application to Maturation of the Immune Response — Use of Antibodies as Molecular Mimics to Probe Intermolecular Interaction Landscapes — Affinity Maturation and Learning in Immune Networks — Auto-Anti-ldiotype and Antigen as Selective Factors Driving B-Cell Affinity Maturation in the Immune System — Somatic Mutation and the Antibody Repertoire: A Computational Model of Shape Space — Applied Molecular Evolution — Evolution of Proteins from Random Sequences: A Model for the Protein Sequence Space and an Experimental Approach — Studies in the Evolution of Biological Activity from Random Sequences — The Catalytic Potential of RNA — Origin of Life Models — Dynamics of Autocatalytic Reaction Networks