Nitric Oxide: Basic Research and Clinical Applications

Nitric Oxide: Basic Research and Clinical Applications

ISBN-10:
1586031643
ISBN-13:
9781586031640
Pub. Date:
08/28/2001
Publisher:
IOS Press, Incorporated
Nitric Oxide: Basic Research and Clinical Applications

Nitric Oxide: Basic Research and Clinical Applications

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Overview

This book deals with mediation by nitric oxide (NO) of many biological functions. Nitric oxide, initially known as Endothelial Derived Relaxing Factor (EDRF, Furchgott, Zawadzki 1980), six years later was identified as nitric oxide. Nowadays, its significance reached clinical applications. Clinical significance of nitric oxide encompasses: a/ application of NO-donors such as nitroglycerin and other organic nitrates or sydnonimines in cardiovascular diseases b/ exploitation of stimulation of nitrergic nerves in bronchial asthma or treatment of male impotence c/ resuscitation of fading endothelial function in diabetes or atherosclerosis by using drugs which stimulate vascular endothelium d/ protection of vascular or cardiac transplants from rejection e/ regulation of renal function f/ management of septic shock patients, and many other applications. Basic research of NO is of utmost importance for its further practical applications. Among the authors of the book there are two Nobel Prize winners, Robert Furchgott and Murad Ferid, in physiology and medicine who received their prize in 1998 for the discovery of biological significance of nitric oxide. This work presents the latest data on: cellular signalling by nitric oxide, structure and activity of nitric oxide synthases, the mode of activation by nitric oxide of soluble guanylate cyclase, the role of formation of peroxynitrites, the mode of inhibition of nitric oxide synthase by drugs, interaction between nitric oxide and other endothelial mediators such as prostacyclin or plasminogen activator, specificity of physiology of isoenzymes of nitric oxide synthase in vascular wall, in brain and in immunological system. Practically, therecent achievements in nitric oxide basic research and therefrom deriving clinical applications - as seen from West and East Europe and the U.S.A. - will all be covered by the chapters of this book. In summary, this book will outline the hottest issues on biology, pharmacology, and biochemistry of nitric oxide, with a sound support from the latest clinical applications of the "NO principle".

Product Details

ISBN-13: 9781586031640
Publisher: IOS Press, Incorporated
Publication date: 08/28/2001
Series: NATO Science Series
Pages: 229
Product dimensions: 6.50(w) x 9.60(h) x 0.80(d)
Age Range: 17 Years

Table of Contents

Prefacev
Lectures
Research Leading to Nitric Oxide: the Importance of Accidental Findings1
Signal Transduction with Nitric Oxide, Guanylyl Cyclase and Cyclic Guanosine Monophosphate5
Mechanism of Oxygen Activation in the NO Synthases, and a Kinetic Model for Catalysis23
The Role of Tetrahydrobiopterin in Nitric Oxide Synthesis27
The Biological Chemistry of Nitric Oxide and Peroxynitrite35
Kinetics of Nitric Oxide and Superoxide Release in the Brain during Ischemia/Reperfusion44
Endogenous Inhibition of NOS and the ADMA/DDAH Pathway53
Role of Endothelial Nitric Oxide in Pleiotropic Action of Cardiovascular Drugs: Nebivolol57
Role of Nitric Oxide in Cardiac Transplant Rejection: Documentation by EPR Spectroscopy and Other Techniques71
Role of Nitric Oxide in Antiarrhythmic Effects of Ischaemic Preconditioning80
Nitric Oxide and The Developing Heart92
Oxidized Lipids and Platelet Activation: Interaction with Nitric Oxide100
Effect of Oxidized LDL on Nitrotyrosines Production in Endothelial Cells108
Nitric Oxide and Circulatory Shock: An Update117
Role of Inducible Nitric Oxide Syntethase and Reactive Oxygen Species in Zymosan--Induced Shock126
Nitric Oxide--A Safeguard of Pulmonary Microcirculation in Early Endotoxaemia137
Posters
Therapeutic Delivery of the Scaffolding Domain Inhibits Nitric Oxide Synthesis and Reduces Inflammation149
Detection of the Antioxidant Activity of Flavonoids by Using a Superoxide Sensor168
Nitric Oxide Reverses the Inhibition of Endocytosis Induced by Tumour Necrosis Factor--[alpha] in Dendritic Cells181
No Effect of Elevated Glucose on the Generation of Endothelium--Derived Nitric Oxide in Rabbit Aorta186
Apoptotic Process Modulated by Nitric Oxide in Chronic B-Cell Lymphocytic Leukemia188
NO-Modulating Selective [beta]-Blocker Nebivolol: Does It Improve Arterial Compliance in Insulin-Resistant Hypertensives?190
Vitamin C and Lipoic Acid Lower Oxidant Production in Cultured HAEC: Implications for Age-Related Endothelial Dysfunction192
The Features of NO Metabolism under Organic Nitrates Biotransformation in Patients with Ischemic Heart Disease195
Genetic Epidemiology of Cardiovascular Diseases in Daghestan Highland Isolates197
The Role of NO in Altered Sensitivity of Vascular Preparations to Drugs in Diabetic Animals199
The Effects of a HMG CoA Reductase Inhibitor, Atorvastatin on Human Isolated Bypass Graft Materials201
Ischaemic Preconditioning of Coronary Vasculature203
Modulatory Role of Nitric Oxide on the PAF-Induced Cardiopulmonary Effects: Interaction between Nitric Oxide Synthase and Cyclooxygenase Pathways204
Characterization of NO Spin Traps: EPR Properties and Trapping Efficiency206
Bradykinin as a Strong Inducer of COX-2 mRNA and a Weak Inducer of NOS-2 mRNA in Cultured Endothelial Cells from Human Umbilical Vein207
Modulation of Nitric Oxide Production by Lysophosphatidylcholine in Human Endothelial Cells210
The Role of Nitric Oxide, Prostacyclin and Melatonin in Aspirin-Sensitive Asthma211
Mechanisms of Regulation of Neurotransmitter Release by Nitric Oxide212
LPS-Induced NO Production in Human T84 Intestinal Epithelial Cells - Characterization and Pharmacological Control216
Modified Method for Capillary Electrophoresis to Determine Nitric Oxide Correlated Nitrate in Tissue Homogenates217
Role of Nitric Oxide on Exercise-Induced Changes in Active Subjects: Effects of Physical Training and Acute Exercise221
Author Index228
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