A Clinical Guide to Inositols

by Vittorio Unfer (Editor), Didier Dewailly (Editor)

Overview

A growing body of research demonstrates the potential benefits of the administration of inositol isomers in the treatment of many different disorders, from reproductive to metabolic diseases.

A Clinical Guide to Inositols discusses scientific evidence of inositol-based treatments in different clinical fields to provide clinicians with a practical guide to use inositol supplementation within pathological conditions. Each chapter covers a specific disorder and describes aspects of the application of inositol in clinical practice, discussing the physio-pathologic features of the health condition and scientific evidences of the effects of inositol treatment.This book is a valuable resource to researchers and clinicians looking for a clear understanding of clinical effects of inositol supplementation and a practical guide on inositol-based treatments.

• Covers basic knowledge about the biochemistry and physiology of inositol and their pharmacological targets and metabolites
• Discusses scientific evidence of the benefits of inositol supplementation for the clinical management of different diseases
• Addresses inositol application from the gynecological and obstetrical field to, among others, the metabolic, fetal, andrological, endocrine, and oncological fields

Product Details

ISBN-13:	9780323985550
Publisher:	Elsevier Science
Publication date:	01/05/2023
Sold by:	Barnes & Noble
Format:	eBook
Pages:	288
File size:	6 MB

About the Author

Vittorio Unfer, MD, is a Professor at the Faculty of Medicine of the University of Modena and Reggio Emilia, Italy, and also works as an Obstetrics and Gynecology specialist, researcher and university lecturer. His research interests include aspects of nutrition and use of food supplements in obstetrics and gynecology clinical practice and the morphofunctional study of uterine contractile activity with previous uterine scar, the triggering mechanisms of labor, the treatment of the threatened miscarriage abortion and prevention of preterm labor in high-risk patients, the treatment of hypogonadotropic male hypogonadism with FSH, and several in-depth and comparative experimentations on the fetal maturity. Prof. Unfer was one of the first researchers studying the use of myo-inositol in the treatment for polycystic ovary syndrome; his in-depth research pointed out the beneficial effects of the myo-inositol molecule on ovarian function and metabolic parameters. He has published numerous articles in reputed journals, including Fertility and Sterility and International Journal of Molecular Sciences.
Dr Didier Dewailly is professor of Endocrinology and Reproductive Medicine in the Lille University Hospital, France. Until 2017, he was head of the Department of Endocrine Gynecology and Reproductive Medicine at the Hôpital Jeanne de Flandre, including an IVF unit. He is now retired from the Hospital, but he still keeps an academic position and coordinates the teaching of Medical Gynecology and Reproductive Medicine for the North-West area of France. He is redactor-in-chief of Médecine-Thérapeutique/Médecine de la Reproduction which is the journal of the French Reproductive Medicine Society whom he is past-President. His main fields of interest in research currently are the female hyperandrogenism (Polycystic Ovary Syndrome (PCOS) and other causes) and Ovulation Disorders such as PCOS, hypothalamic amenorrhea, hypogonadotropic hypogonadism and premature ovarian failure.

Table of Contents

1. Introducing inositols and their clinical targets: physiology and pathophysiology
2. Effectiveness of Myo- and D-chiro-inositol in the treatment of metabolic disorders
3. Treating PCOS with inositols: choosing the most appropriate myo- to D-chiro-inositol ratio
4. Overcoming inositol-resistance
5. Inositol supplementation for preventing Gestational Diabetes Mellitus
6. Inositol efficacy on the incidence of adverse fetal outcomes
7. Treatments with inositols in the IVF procedures
8. Supplementation with D-chiro-inositol in women
9. Application of myo-inositol and D-chiro-inositol in andrological issues
10. Myo-inositol supplementation for subclinical hypothyroidism
11. Respiratory distress and treatment with Myo-inositol to reduce pulmonary inflammation
12. Inositols as adjuvant treatments in oncology
13. Myo-inositol supplementation restores inositol depletion induced by treatments for psychiatric and neurological conditions

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From the Publisher

Discusses evidence of inositol-based treatments in different clinical fields to provide clinicians with a practical guide to use inositol supplementation

Editorial Reviews

Reviewer: Jessica Hwang, MD (Edward Hines, Jr. VA Hospital)
Description: This book provides an in-depth look into inositols: defining them, exploring disease conditions affected by deficiency or excess, and discussing how these levels can be restored or decreased and the subsequent effects.
Purpose: Previous literature mostly focuses on the metabolic and gynecologic applications of inositols. This book reviews these roles, but also explains their wider-reaching effects with possible neurologic, psychologic, or oncologic implications.
Audience: The book will benefit individuals interested in pharmaceutical research and development. The contributors draw from various fields such as endocrinology, obstetrics/gynecology, and cancer research, and many are part of the Experts Group on Inositol in Basic and Clinical Research. Dr. Vittorio Unfer is a professor in the Faculty of Medicine at the University of Modena and Reggio Emilia, Italy, and works as an obstetrics and gynecology specialist and researcher. He has conducted research on myo-inositol supplementation in polycystic ovary syndrome (PCOS). Dr. Didier Dewailly is Professor of Endocrinology and Reproductive Medicine in the Lille University Hospital, France. Until 2017, he was head of the Department of Endocrine Gynecology and Reproductive Medicine at the Hôpital Jeanne de Flandre, including an in vitro fertilization (IVF) unit.
Features: Each chapter begins with an introduction, then explains how inositols are relevant to a given organ system. The chapters include extensive references, with limited tables and figures.
Assessment: There are no other comparable books discussing the clinical implications of inositols.

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