A Handbook of Bioanalysis and Drug Metabolism / Edition 1

by Gary Evans

Overview

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now.

A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills.

This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

Product Details

ISBN-13:	9780367394424
Publisher:	Taylor & Francis
Publication date:	09/25/2019
Edition description:	Reprint
Pages:	408
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

The Role of Drug Metabolism and Pharmacokinetics in Drug Discovery: Past, Present and Future. The Importance of the Physiochemical Properties of Drugs to Drug Metabolism. Sample Preparation. High Performance Liquid Chromatography in Pharmaceutical Bioanalysis. Quantitative Mass Spectronomy. Immunoassay in Bioanalysis. Phase I Metabolism. Phase II Enzymes. In vitro Techniques for Investigating Metabolism. Drug–Drug Interactions: an in vitro Approach. Clinical Impact of Drug Interactions. Preclinical Pharmacokinetics. Pharmacokinetic / Pharmacodynamic Modeling in Preclinical Drug Discovery. Toxicokinetics. Protein Binding in Plasma: A Case History of a Highly Protein Bound Drug. Metabolite Identification by Spectroscopy. Whole Body Autoradiography. Radiolabeled Studies in Man. Molecular Biology.

Editorial Reviews

3 Stars from Doody

Reviewer: Gregory Reed, PhD (University of Kansas Medical Center)
Description: This book pulls together relevant aspects of analytical chemistry, biochemistry and molecular biology, immunology, pharmacology and toxicology, and physiology as they apply to the study of drug disposition.
Purpose: Effective planning, execution, and interpretation of studies in drug disposition requires an appropriate understanding of several separate areas of science. In the past this broad training was accomplished by following directions from senior investigators and by heeding their advice, while at the same time trying to recall principles taught didactically in very different contexts. This book aims to accelerate the training process by assembling the key theoretical and practical aspects of many areas and then stressing their application to the study of drug disposition. This is a highly worthy goal, and one that the book generally meets.
Audience: The book is proposed as a text for senior undergraduate and graduate students, primarily those enrolled in pharmaceutical and chemical science programs. This audience could well be broadened to include post-docs and professionals in related fields, and even to experienced practitioners as a refresher course.
Features: The first half of the book focuses on bioanalysis and on the use of the resultant data for pharmacokinetic and pharmacodynamic modeling. These chapters are quite straightforward in their ordering and their individual presentations. The subsequent sections discuss phase I and II enzymes and metabolism, in vitro approaches in drug metabolism, and the role of molecular biology in the field. These chapters, especially the metabolism and the molecular biology chapters, are somewhat problematic. The scope of the book requires that these be simplified and rather minimalist presentations of these areas, but this restriction sometimes lessens the clarity and, on a few occasions, the accuracy of what is presented.
Assessment: The potential value of a single-source teaching and reference book for bioanalysis and drug metabolism, as opposed to having to mine relevant sections of numerous separate book, is great. This book is a worthy attempt. For a more detailed and broader treatment strictly of bioanalysis, Venn's Principles and Practice of Bioanalysis (Taylor & Francis, 2000) is preferred, but that book lacks the extensions to both the molecular side (enzymes, molecular biology) and to the whole organism side (pharmacokinetics, pharmacodynamics) that this book provides.

Doody's Review Service