Adrenomedullin in Cardiovascular Disease / Edition 1

by Toshio Nishikimi

Overview

Adrenomedullin was discovered in 1993 in an extract of human pheochromocytoma while monitoring cAMP levels in rat platelets. Adrenomedullin has attracted considerable interest among cardiologists due to its impact on the cardiovascular system which includes a decrease in blood pressure in vivo; an impact on vascular smooth muscle cells; increases cAMP levels; indirectly reduces blood pressure and has role in the pathogenesis of arteriosclerosis.

Adrenomedullin in Cardiovascular Disease is an up-to-date review of the most relevant aspects of adrenomedullin. It encompasses a broad range of fields including biochemistry, molecular biology, physiology, pharmacology, pathophysiology of cardiovascular disease and clinical applications of adrenomedullin to cardiovascular disease.

Product Details

ISBN-13:	9781489994295
Publisher:	Springer US
Publication date:	12/02/2014
Series:	Basic Science for the Cardiologist , #19
Edition description:	2005
Pages:	219
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Toshio Nishikimi, MD, PhD, is an Associate Professor in the Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.

Table of Contents

Biochemistry of Adrenomedullin.- Adrenomedullin Receptor and Signal Transduction.- Adrenomedullin Gene.- Adrenomedullin Expression and Secretion.- Biological Action of Adrenomedullin.- Circulating Adrenomedullin.- Role of Adrenomedullin in Cardiovascular Diseases.- Adrenomedullin as an Adipokine.- Adrenomedullin Knockout Mouse and Transgenic Mouse.- Pleiotropic Effect of Adrenomedullin: Lessons from Pure Adrenomedullin Knockout Mouse.- Therapeutic Application of Adrenomedullin.- Therapeutic Potentials of Adrenomedullin for Heart Failure and Pulmonary Hypertension.

Editorial Reviews

3 Stars from Doody

Reviewer: Gustavo A Cardenas, MD (Ochsner Clinic Foundation)
Description: The authors effectively review the most relevant available information about adrenomedullin, a vasoactive peptide that contributes to the control of circulatory system and body fluid homeostasis. They integrate basic science information with published clinical studies and potential clinical applications of this peptide in a well organized, compact, and easy to read textbook of cardiovascular neuroendocrinology.
Purpose: The purpose is to summarize the current knowledge base pertaining to adrenomedullin, from the bench to the bedside, and its growing importance in cardiovascular medicine.
Audience: This book is intended for clinicians and researchers in cardiovascular medicine, especially for those who have a particular interest in the topic of hormones and cardiovascular disease.
Features: Each of the 12 chapters discusses relevant aspects of adrenomedullin, across a broad range of disciplines including biochemistry, molecular biology, physiology, pharmacology, pathophysiology, and clinical applications of adrenomedullin in cardiovascular disease. The last two chapters summarize the experience with adrenomedullin in the treatment of cardiovascular diseases as well as the future therapeutic applications. Each chapter is easy to read and incorporates an informative introduction, objectives of the chapter, a thorough discussion of the available data, and concise conclusions.
Assessment: The authors, who are experts in cardiology and its neuroendocrine control, succeed in providing an up-to-date, easy to read review of the most relevant aspects of adrenomedullin. It encompasses a broad range of disciplines including biochemistry, molecular biology, physiology, pathophysiology, and clinical applications with evidence-based information that is of interest to clinicians, clinician researchers, and basic scientists in cardiovascular medicine.

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