Adult Neurogenesis: (Cold Spring Harbor Monograph Series 52)

by Fred H. Gage, Gerd Kempermann, Hongjun Song

Overview

The idea that the adult brain of mammals can generate new neurons has only recently been accepted by the scientific community, and research in this exciting area is now in full swing. Bringing together leading researchers in the field of adult neurogenesis, the 30 chapters in this monograph provide a valuable overview of this emerging field and lay the groundwork for future studies. Adult Neurogenesis includes discussions on neural stem cell biology; methods and models for studying adult neurogenesis; physiological and molecular processes and their control; related neurological diseases; and comparisons of neurogenesis in humans, birds, fish, and invertebrates. It will be of interest to all researchers in neurobiology as well as those in the medical field, as it has implications for understanding depression, epilepsy, and other psychiatric disorders.

Product Details

ISBN-13:	9780879697846
Publisher:	Cold Spring Harbor Laboratory Press
Publication date:	11/15/2007
Series:	Cold Spring Harbor Monograph Series , #52
Edition description:	New Edition
Pages:	865
Product dimensions:	9.08(w) x 6.42(h) x 1.30(d)

About the Author

Date of Death:

January 4, 2009

Table of Contents

Preface   F.H. Gage   G. Kempermann   H. Song     xi
Adult Neurogenesis: A Prologue   F.H. Gage   H. Song   G. Kempermann     1
Methods
In vivo approaches
Numerology of Neurogenesis: Characterizing the Cell Cycle of Neurostem Cells   R.S. Nowakowski   N.L. Hayes     7
Detection and Phenotypic Characterization of Adult Neurogenesis   H.G. Kuhn   D.A. Peterson     25
Evolving Methods for the Labeling and Mutation of Postnatal Neuronal Precursor Cells: A Critical Review   J.J. Breunig   J.D. Macklis   P. Rakic     49
The Use of Reporter Mouse Lines to Study Adult Neurogenesis   G. Enikolopov   L. Overstreet-Wadiche     81
Retrovirus-mediated Cell Labeling   C. Zhao     101
In vitro approaches
Neurospheres   I. Singec   A. Quinones-Hinojosa     119
Monolayer Cultures of Neural Stem/Progenitor Cells   J. Ray     135
Basic Processes
Neurogenesis in the Adult Hippocampus   G. Kempermann   H. Song   F.H. Gage     159
Adult Subventricular Zone and Olfactory Bulb Neurogenesis   D.A. Lim   Y.-C. Huang   A. Alvarez-Buylla     175
Neurogenic Niches in the Adult Mammalian Brain   D.K. Ma   G.-l. Ming   F.H. Gage   H. Song     207
Molecular and Physiological Mechanisms
Adult Neurogenesis: Similarities and Differences in Stem Cell Fate, Proliferation, Migration, and Differentiation in Distinct Forebrain Regions   D.C. Lie   M. Gotz     227
Proneuronal Genes Drive Neurogenesis on the Road from Development to Adulthood   E.T. Buchen   S.J. Pleasure     267
The Balance of Trophic Support and Cell Death in Adult Neurogenesis   H.G. Kuhn     283
Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus   J. Bischofberger   A.F. Schinder     299
Regulation
Genetics and Epigenetics in Adult Neurogenesis   J. Hsieh   J.W. Schneider     321
Activity Dependency and Aging in the Regulation of Adult Neurogenesis   G. Kempermann     341
Regulation of Hippocampal Neurogenesis by Systemic Factors Including Stress, Glucocorticoids, Sleep, and Inflammation   P.J. Lucassen   C.A. Oomen   A.-M. van Dam   B. Czeh     363
Regulation of Adult Neurogenesis by Neurotransmitters   M.-H. Jang   H. Song   G.-l. Ming     397
Functional Significance
Adult Neurogenesis in the Olfactory Bulb   P.-M. Lledo     425
Neurogenesis and Hippocampal Memory System   D.N. Abrous   J.M. Wojtowicz     445
Computational Modeling of Adult Neurogenesis   J.B. Aimone   L. Wiskott     463
Neurological Diseases
Hippocampal Neurogenesis: Depression and Antidepressant Response   A. Sahay   R. Hen   R.S. Duman     483
Adult Neurogenesis in Neurodegenerative Disease   P. Brundin   J. Winkler   E. Masliah     503
Epilepsy and Adult Neurogenesis   S. Jessberger   J.M. Parent     535
Neurogenesis following Stroke Affecting the Adult Brain   O. Lindvall   Z. Kokaia     549
Comparative Neurogenesis
Adult Neurogenesis in Teleost Fish   G.K.H. Zupanc     571
Neurogenesis in the Adult Songbird: A Model for Inducible Striatal Neuronal Addition   S.A. Goldman     593
Adult Human Neurogenesis: A Response to Cell Loss and New Circuitry Requirements?   M.A. Curtis   P.S. Eriksson   R.L.M. Faull     619
Adult Hippocampal Neurogenesis in Natural Populations of Mammals   I. Amrein   H.-P. Lipp   R. Boonstra   J.M. Wojtowicz      645
Index     661

Editorial Reviews

The study of adult neurogenesis has grown exponentially over the past decade. New papers are being published almost daily, making any attempt to summarize the field a daunting task. Nevertheless, the editors and authors of Adult Neurogenesis have managed to assemble a comprehensive review of current research. Organized into seven sections that encompass 30 chapters covering topics ranging from the detection of adult-generated neurons to their possible role in neurological and psychiatric disease, the book provides a truly panoramic picture. The editors acknowledge that the volume presents only a 'snapshot' of the current field...but its comprehensive nature makes it a valuable collection of knowledge and ideas in this burgeoning area of neuroscience.

Nature Neuroscience

Given the size of the literature on the subject of neurogenesis, it would be convenient to have most of the existing information compiled in an easily accessible form. Adult Neurogenesis by Gage, Kempermann, and Song is a recently published book that fills this niche by covering many aspects of this intriguing phenomenon....[T]he book is an authoritative source that provides wide coverage of the major topics of the field.

Neuron