Advanced Mechanical Models of DNA Elasticity

by Yakov M Tseytlin

Overview

Advanced Mechanical Models of DNA Elasticity includes coverage on 17 different DNA models and the role of elasticity in biological functions with extensive references. The novel advanced helicoidal model described reflects the direct connection between the molecule helix structure and its specific properties, including nonlinear features and transitions. It provides an introduction to the state of the field of DNA mechanics, known and widely used models with their short analysis, as well as coverage on experimental methods and data, the influence of electrical, magnetic, ionic conditions on the persistence length, and dynamics with viscosity influence. It then addresses the need to understand the nature of the non-linear overstretching transition of DNA under force and why DNA has a negative twist-stretch coupling.

Product Details

ISBN-13:	9780128019993
Publisher:	Elsevier Science
Publication date:	04/07/2016
Pages:	316
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

YAKOV M. TSEYTLIN is a mechanical engineer, educator, and research scientist. Born in Leningrad, Russia; he arrived in the USA in 1992, becoming naturalized in 1997. His qualifications and professional positions include: MS in Mechanical Engineering, Leningrad Polytechnic Institute, PhD, 1965; Doctor of Technical Sciences, All-Russian Research Institute of Metrology, Russia, 1991; Chief of research laboratory, senior designer, senior and lead researcher, Leningrad Instrumental Plant, All-Russian Research Institute of Metrology, Russia; senior designer, senior researcher Federal Products Co. USA, 1992; project engineer in Automatic Machinery Co. US, 1999; assistant to associate professor in Leningrad Polytechnic Institute; visiting professor in Leningrad Institute of Precise Mechanics and Optics; Manager and Engineer, All-Russian Institute of Advanced Education in Standardization and Metrology;

Adviser and Opponent of Graduate Dissertations in Central Research Institute for Fuel Apparatus, All-Russian Research Institute of Metrology, Leningrad Polytechnic Institute. He has contributed numerous articles to professional journals, and authored 4 monographs. He is also a member of International Society of Automation (recognition awards 1998-2012, ISA). His achievements include development of methods and concepts in micro elasticity, DNA elasticity modeling, atomic force microscopy, and information criterion of measurement uncertainty negligibility.

Table of Contents

1. DNA Molecules Mechanical Properties and Models2. Force Application, Measurement, and Manipulation Accessories3. AFM with Higher Mode Oscillations and Higher Sensitivity4. Kinematics and Nonlinear Motion Transformation in Elastic Helicoids 5. Dynamics of the Elastic Systems with Helicoids6. Double-Stranded DNA Elasticity 7. DNA Elasticity with Transition

What People are Saying About This

From the Publisher

This helpful research companion provides a contemporary approach to examining 17 different DNA models and the role of elasticity in biological functions, and contains extensive references about the novel models featured along with an introduction to the state of the field of DNA mechanics

Editorial Reviews

"...an extremely useful book that describes the important concepts of advanced mechanical models of DNA elasticity and discusses extensive technical details, providing an effective way to get a better understanding of DNA mechanical features and functions. Score: 91 - 4 Stars" —Doody's

From the Publisher

Reviewer: Omer M. Iqbal, MD, FACC, FESC (Loyola University Medical Center)
Description: This interesting book details in a comprehensive fashion how 17 different DNA models and the principles of elasticity operate across a wide range of biological functions.
Purpose: The purpose is to help develop new and more advanced mechanical models of DNA elasticity and provide effective means for the better understanding of DNA mechanical features and functions.
Audience: In my judgment, the book is intended for molecular biologists and others interested in learning about advanced mechanical models of DNA elasticity.
Features: The first chapter deals with the mechanical properties of DNA molecules and discusses several effective mechanical models of DNA elasticity including the freely joined chain (FJC), worm-like chain (WLC), helical wormlike chain (HWC), and discrete persistent chain (DPC) models. Chapter 2 discusses the development of experimental research methods for determining the mechanical properties of DNA, while chapter 3 covers atomic force microscopy with higher vibration modes and sensitivity, up to zeptogram and femtometers. Chapter 4 explores the kinematics of an elastic helicoidal beam and its physical realization in the thin pretwisted (helicoidal) micro-nanostrips, an important part of a new explicit functional helicoidal model of DNA. Chapter 5 covers the dynamics and vibration of elastic helicoids, their periodic and transient functions. Chapter 6 discusses double-stranded DNA elasticity and chapter 7 covers DNA elasticity and transition. The unique features of this book are the illustrations and numerous calculations useful in gaining an understanding of this complex subject.
Assessment: This is an extremely useful book that describes the important concepts of advanced mechanical models of DNA elasticity and discusses extensive technical details, providing an effective way to get a better understanding of DNA mechanical features and functions.

Doody's Review Service