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Overview
Advances in Clinical Chemistry, Volume 123, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists.
Product Details
ISBN-13: | 9780443297007 |
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Publisher: | Elsevier Science |
Publication date: | 05/16/2024 |
Series: | Advances in Clinical Chemistry , #120 |
Pages: | 208 |
Product dimensions: | 6.00(w) x 9.00(h) x 0.00(d) |
About the Author
Dr Gregory S Makowski is a board-certified clinical chemist and fellow of the National Academy of Clinical Biochemistry. Following receipt of his PhD in Biochemistry from the University of Connecticut Storrs, he pursued post-doctoral studies at the University of Connecticut School of Medicine in Farmington that culminated in joint appointments in the School of Medicine and the Department of Laboratory Medicine at John Dempsey Hospital. He has numerous clinical and basic science publications and serves on various scientific and editorial boards. He is actively engaged in the training of Pathology residents and fellows in the Department of Pathology and Laboratory Medicine at Hartford Hospital. He currently serves as Vice President Clinical Laboratory Services Hartford HealthCare in Connecticut.
Table of Contents
Contributors ix
Preface xi
Caspases in Myocardial Infarction Nina Zidar Jeruc Jera Jerse Maja Stajer Dusan
Abstract 1
Introduction 2
Apoptosis and the Heart 3
Caspases 3
Activation of Caspases 4
Activation of Caspases in the Heart 5
Functional Significance of Caspases 6
Caspases for Detection of Apoptosis 9
Apoptosis and Caspases in MI 11
Apoptosis of Cardiomyocytes in Ventricular Remodeling After MI 14
Apoptosis of Other Cell Types in the Evolution of Fibrous Scar 15
Anti-Caspase Treatment 18
Conclusion 23
References 23
Deamidated Gliadin Peptides as Targets for Celiac Disease-Specific Antibodies Thomas Mothes
Abstract 36
Introduction 36
Prolamins as Cereal Storage Proteins 37
Pathogenesis of CD 38
Serological Diagnosis of CD 42
Gliadin Antibodies of CD Patients Recognize Deamidated Gliadin 45
Enhanced Diagnostic Potential of Glutamine-Glutamic Acid Substituted Gliadin-Analogous Peptides 47
Does Epitope Specificity of Gliadin Antibodies of CD Patients Mirror Substrate Specificity of tTG? 49
Relation Between B- and T-Cell Epitopes of Gliadin 51
Conclusions 52
References 53
Urokinase Receptor Variants in Tissue and Body Fluids Gunilla Hoyer-Hansen Ida Katrine Lund
Abstract 66
Introduction 67
Monoclonal Antibodies to uPAR 77
Immunoassays for the Quantification of uPAR 79
uPAR in Cancer 82
Other Diseases 91
Conclusions and Perspectives 91
References 93
Proteomics in Cancer M. A. Reymond W. Schlegel
Abstract 104
Introduction 104
Sampling for Proteomic Analysis 106
Proteomic Technologies Used in Cancer Proteomics 110
Proteomic Applications in Cancer 114
What Has Been Achieved in Cancer Proteomics? 127
Conclusion 133
References 134
Paraneoplastic Neurological Syndromes and Onconeural Antibodies: Clinical and Immunological Aspects Anette Storstein Christian A. Vedeler
Abstract 144
Introduction 144
Onconeural Antigens 148
Paraneoplastic Syndromes of the CNS 149
PNS of the Peripheral Nervous System 155
Paraneoplastic Nervous System Syndromes of the Neuromuscular Junction 159
Diagnosis of Paraneoplastic Nervous System Syndromes 159
Pathogenesis of Paraneoplastic Nervous System Syndromes 165
Therapy for Paraneoplastic Nervous System Syndromes 170
Future Aspects 172
References 172
Pathophysiological Mechanisms of Angiogenesis David A. Walsh
Abstract 188
Introduction 189
Measuring the Angiogenic Process 191
Endothelial Cells and the Initiation of Angiogenesis 193
Differential Angiogenic Pathways 198
Impact of the Vessel's Environment on Angiogenesis 204
Angiogenesis Biomarkers for Assessing Human Disease 205
Therapeutic Targeting of Angiogenesis 210
Conclusion 211
References 212
Bikunin (Urinary Trypsin Inhibitor): Structure, Biological Relevance, and Measurement Michael J. Pugia Roland Valdes, Jr. Saeed A. Jortani
Abstract 224
Introduction 225
Roles in Biological Processes 230
Diagnostic Testing 233
Pathophysiology of Bik 235
Summary 240
References 240
Gene Expression Assays Janine Kirby Paul R. Heath Pamela J. Shaw Freddie C. Hamdy
Abstract 248
Introduction 248
The Technology 250
Gene Expression Assays in Cancer 256
Applications of Arrays to Neurological Disorders 265
Application of Microarrays to Neuropsychiatric Disorders 277
Future Advances 281
References 282
Index 293
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