Advances in Surgical Pathology: Lung Cancer

by Philip T. Cagle, Timothy Allen

Overview

Advances in Surgical Pathology: Lung Cancer, a volume in the Advances in Surgical Pathology series, features chapters on current and impending changes in the field of lung cancer that directly affect pathologists. This includes the 2004 updates of the WHO Classification of Tumors of the Lung; the ongoing new classification of neuroendocrine carcinomas of the lung by the International Association for the Study of Lung Cancer; the ongoing revision of the pathologic and clinical staging of lung cancer by the AJCC; molecular diagnostics in the diagnosis of lung cancer; the role of the pathologist in the new molecular targeted therapies for lung cancer; and the new use of image-guided, multimodality theranostics for the diagnosis and treatment of lung cancer. Other current topics discussed include new understanding of the premalignant and preinvasive lesions and the controversies and revisions of the diagnosis of bronchioloalveolar carcinoma.

Product Details

ISBN-13:	9781451148176
Publisher:	Wolters Kluwer Health
Publication date:	03/28/2012
Series:	Advances in Surgical Pathology
Sold by:	Barnes & Noble
Format:	eBook
Pages:	304
File size:	37 MB
Note:	This product may take a few minutes to download.

Table of Contents

Series Overview vii

Preface ix

Section I Overview of Lung Cancer

1 Epidemiology and Demographics of Lung Cancer Philip T. Cagle 3

2 Clinicopathologic Overview of Lung Cancer Philip T. Cagle 5

Section II Histopathology

3 Adenocarcinoma Philip T. Cagle Keith M. Kerr 11

4 Bronchioloalveolar Carcinoma/Adenocarcinoma-in-Situ Philip T. Cagle Keith M. Kerr 28

5 Proposed Revisions to the Classification of Adenocarcinoma Philip T. Cagle Keith M. Kerr 47

6 Squamous Cell Carcinoma Timothy Craig Allen 54

7 Adenosquamous Carcinoma Timothy Craig Allen 66

8 Large Cell Carcinoma Timothy Craig Allen 71

9 Small Cell Carcinoma Mary Beth Beasley 84

10 Typical Carcinoid Tumor Mary Beth Beasley 98

11 Atypical Carcinoid Tumor Mary Beth Beasley 109

12 Update on Classification of Neuroendocrine Carcinomas Mary Beth Beasley 117

13 Sarcomatoid (Sarcomatous) Carcinoma Sanja Dacic 128

14 Giant Cell Carcinoma Sanja Dacic 135

15 Pulmonary Blastoma Sanja Dacic 139

16 Salivary Gland-like Carcinomas Sanja Dacic 145

17 Metastatic Tumors to the Lung Timothy Craig Allen 153

Section III Imaging

18 Current Imaging Techniques for the Diagnosis and Staging of Lung Cancer Philip T. Cagle Ronald E. Fisher 171

19 Correlation of Imaging with Pathology of Lung Cancer Philip T. Cagle Ronald E. Fisher 175

20 Multimodality Theranostics and Molecular Imaging in the Diagnosis and Treatment of Lung Cancer Kirtee Raparia Kelvin Wong Stephen Wong King C. Li Philip T. Cagle 179

Section IV Molecular Pathology

21 Molecular Diagnostics of Lung Cancer Sanja Dacic 189

22 Molecular Targeted Therapy of Lung Cancer Sanja Dacic 198

23 Molecular Prognostic Markers of Lung Cancer Sanja Dacic 205

Section V Staging

24 Problems in the Staging of Lung Cancer Philip T. Cagle 211

25 New Staging System for Lung Cancer Philip T. Cagle 219

Section VI Preneoplastic and Preinvasive Lesions

26 Bronchial Squamous Dysplasia and Carcinoma in Situ Keith M. Kerr 227

27 Atypical Adenomatous Hyperplasia Keith M. Kerr 245

28 Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia Keith M. Kerr 263

29 Preexisting Lung Disease and Lung Cancer Keith M. Kerr 275

30 Lung Cancer Stem Cells Timothy Craig Allen 288

Index 297

Editorial Reviews

Reviewer: Rashna Madan, M.B.B.S.(University of Kansas Medical Center)
Description: This is a comprehensive review of the current approach to lung cancer from a pathologist's perspective.
Purpose: Pathologists are frequently required to diagnose lung cancer. How they do so, as well as the subsequent testing that minute tissue often requires, is currently subject to modification. Treatment decisions hinge on the accurate typing of carcinoma, and nonsquamous non-small-cell lung carcinomas will often require molecular testing. It also has been proposed that the International Multidisciplinary Classification of Lung Adenocarcinoma include a more accurate and standardized terminology for pulmonary adenocarcinomas. To better understand and appropriately tackle all these changes, the authors have designed "a pragmatic tool for study and for practice."
Audience: The primary audience is pathologists and pathologists in training who deal with the day to-day diagnosis of lung cancer or present to fellow clinicians at tumor boards. It also can be used for board examination study. Clearly, this is a good resource from established authorities on the subject, both as a guide for daily practice and as a means to be an informed participant at multidisciplinary conferences.
Features: The book deals fairly extensively with the histopathology of the various types of epithelial pulmonary malignancy, spanning carcinoid tumors, common and unusual primary carcinomas, and metastases. There are numerous images and subsections covering morphology, immunohistochemistry, and, importantly, the differential diagnosis. Current and proposed classifications and the clinical relevance of these diagnoses are elaborated. Precursor lesions are described in similar fashion. Issues with the current staging are discussed as well. Molecular derangements, a topic currently at the forefront of pulmonary carcinoma, is dealt with via chapters on their methodology and predictive and prognostic significance. Evolving diagnostic and therapeutic modalities are also briefly touched on. As this book deals with epithelial malignancies, it does not discuss benign tumors and nonepithelial malignancies. Cytology is very briefly described; given how frequently this modality is used for diagnosis, slightly greater detail on distinguishing cytologic features would not have been amiss. Finally, while the role of immunohistochemistry is clearly described, adding tables or diagnostic algorithms may have been helpful.
Assessment: This is an intelligent, current review of lung cancer for practicing pathologists and those in training. It is a handy source to use to keep abreast of all the advances in the field.

Doody's Review Service