4 [four]new relevant findings that would help advance the course of medical science are reported here with their clinical significance viz:
1.TNF-A gene levels exist in two levels, high[3mg/dl] and low[1mg/dl], Pre-marital screening in addition to the already existing ABO, and Rhesus Factor, is herby recommended and should be undertaken to avoid some marital issues including, uterine fibroid,PCOS, as well as azospermia and oligospermia refractile to medical treatment and possibly other yet to be identified diseases.
2.
Raised ESR[15-100], reduced platelet count[148000-180000], and increased clotting time by >60% simultaneously could signal an expression of platelet derived growth factor from both uterine tumours as well as ovarian tumours.Such would need more aggressive approach including surgery to correct the associated pathologies which if left could lead to cancer especially in lesions of more than 5years.In resource limited environment, the cost of these three tests is just less than 20% of the cost of doing PCR test for PDGF assay, so it makes sense especially in epidemiological studies. Soluble HLA G molecule is increased in malignancies and enable pro-inflammatory cytokines production and activity of which platelet consumption as well as raised ESR feature, so it corresponds to expression of Platelet derived growth factor an indication that neoplasia have occurred long before metastasis could happen.
3.Revision of scar to restore the firmness or turgidity of the penile shaft in an elderly man 65 years of age who lost it due to bullous impetigo lesions destroying the adyin filaments of the skin,from mixed infection of staphylococus aureus and c,albicans also proved helpful.It made the man and woman happier and reduced tension which could have escalated from unproven suspicions. Marriages could be happier and may be divorce avoided with less quarrels and suspicions.
4. Dermoid cyst or bilateral mature cystic terratoma of the ovaries can occur, as opposed to unilateral lesions that had been earlier documented. Host derived factors, including ingested phyt-oestrogen rich herbal medications locally prepared, interacting with invading pathogens particularly serial rise in Candidalysin titre as well as viral infection co-existing with staphylococcus aureus are suspect mechanisms involved in the de-differentiation of stem cells to generate skin appendages like hair, sebaceous gland, nail or teeth that are often seen in the benign tumor. Early screening and monitoring from 11-12 years or perpubertal in females could help prevent, the incidence of dermoid cyst.
