AIDS Pathogenesis / Edition 1

by H. Schuitemaker, Frank Miedema

Overview

Infection with the human immunodeficiency virus is characterized by the destruction of the host immune system as also reflected by a progressive loss of CD4-positive T-cells. This finally results in the host's incapacity to deal with opportunistic infections and the immune surveillance of tumors, a clinical status known as the Acquired Immunodeficiency Syndrome (AIDS).
The book AIDS Pathogenesis provides the reader with a complete overview of the clinical course of HIV-1 infection. It describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. In addition, more fundamental aspects of HIV-1 infection are reviewed. These include the biology of the virus and the novel insights in AIDS pathogenesis. Not only is the significance of an HIV-specific cellular and humoral immune response discussed, but also the possible incapacity of the adult human host to deal with T-cell destruction. Finally, the book discusses the currently used laboratory markers that allow for monitoring of the clinical course of infection.

Product Details

ISBN-13:	9789048154074
Publisher:	Springer Netherlands
Publication date:	12/07/2010
Series:	Immunology and Medicine , #28
Edition description:	Softcover reprint of the original 1st ed. 2000
Pages:	284
Product dimensions:	6.10(w) x 9.25(h) x 0.02(d)

About the Author

Schuitemaker, Hanneke (Univ of Amsterdam); Miedema, Frank (Univ of Amsterdam)

Table of Contents

Aids Pathogenesis: Table of Contents.- 1 HIV-1 transmission.- 2 Primary HIV infection.- 3 Biological variability of HIV-1.- 4 T-cell dynamics and renewal in HIV-1 infection.- 5 Long-term non-progressive HIV infection.- 6 Cytotoxic T lymphocytes in HIV-1 infection.- 7 Mechanisms and in-vivo significance of HIV-1 neutralisation.- 8 Suppression of primate immunodeficiency lentiretroviruses CD8+ T-cell-derived soluble factors.- 9 Opportunistic infections.- 10 — AIDS-related non-Hodgkin’s lymphomas.- — Pathogenesis of Kaposi’s sarcoma.- 11 AIDS dementia complex.- 12 Anti-retroviral therapy and resistance to anti-retroviral drugs.- 13 Prognostic markers and immunological reconstistution during HIV-1 infection.- 14 HIV-viral load.- 15 — The SCID-hu mouse: an in-vivo model for HIV-1 infection in humans.- — Non-human primate models for HIV-1 infection.

Editorial Reviews

Provides a complete overview of the clinical course of HIV-1 infection and describes the clinical aspects of primary infection, the different clinical outcomes of HIV-1 infection, and strategies for anti-viral treatment. Reviewed items include viral biology and insights into AIDS pathogenesis. Editors Schuitemaker and Miedema (both at CLB and Laboratory for Experimental and Clinical Immunology, U. Of Amsterdam) have assembled a series of highly technical studies like "Cytotoxic Lymphocytes in HIV-1 Infection" and "Suppression of Primate Immunodeficiency Lentiretroviruses by Cd8+T-Cell-Derived Soluble Factors" written by scientists from Canada, the U.S., Europe, and Australia. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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