Alkaloids: Chemical and Biological Perspectives

by S.W. Pelletier

Overview

Acronycine, a potent antitumor agent, was discovered in the bark of the small Australian Rutaceous tree, Acronychia baueri Schott. This new work presents a comprehensive survey of the isolation, structure determination, methods of synthesis, and the biological properties of acronycine, as well as an account of natural and synthetic analogues of acronycine, and their biological properties.
Solanum alkaloids were reviewed in 1990 and this book surveys the new developments (isolation procedures, structural elucidation methods) and critically updates earlier reviews. In addition it presents the interesting chemistry and synthesis of cyclopeptide alkaloids. These cyclopeptide alkaloids have been isolated from ascidians, sea hares, and cyanobacteria. Also included are reviews of the use of the functionalized lactam, pyroglutamic acid, as a chiral template for the synthesis of alkaloids. The second review examines the on-line coupling of capillary electrophoresis (CE) and mass spectrometry (MS) for the analysis of alkaloid mixtures. Finally a review of oxygenated analogs of the alkaloid Marcfortine for their potent antiparasitic activity is included at the end of this work.
Each chapter in this volume has been reviewed by at least one expert in the field. Indexes for both subjects and organisms are provided.

Product Details

ISBN-13:	9780080440255
Publisher:	Elsevier Science
Publication date:	12/03/2001
Series:	Alkaloids: Chemical and Biological Perspectives , #15
Pages:	656
Product dimensions:	6.12(w) x 9.21(h) x (d)

Table of Contents

The bisbenzylisoquinoline alkaloids – a tabular review (P. L. Schiff, Jr.)
Alkaloids from Malaysian flora (Toh-Seok Kam)
Applications of palladium chemistry to the total syntheses of naturally occurring indole alkaloids (Jie Jack Li)
Subject index
Organism index.

Editorial Reviews

from:Geoffrey A. Cordell
"This is the eleventh in the series of volumes intitiated in 1983 to complement The Alkaloids: Chemistry and Pharmacology series of Academic Press. This particular volume brings together five chapters, one major contribution from Paul Schiff and four shorter contributions from a distinguished group of authors, which collectively maintain the quality of the series. Schiffs' marvellous tour-de-force demonstrates his preeminent knowledge of the alkaloids of Thalictrum species, and it is both refreshing and inspiring to see the wealth of data on these diverse alkaloid groups presented in such a lucid and well-organised manner....Overall this volume is strongly recommended for university and corporate libraries..." —Journal of Natural Products

From the Publisher