Alzheimer Disease: From Molecular Biology to Theraphy

by Robert Becker, Ezio Giacobini

Overview

This volume reviews the new potential treatments and research in the area of Alzheimer's disease. Special attention is given to international developments in all fields relevant to new drug development. Topics discussed include: progress in the international harmonization of drug development guidelines for dementia drugs; bioethics and law; development of rating instruments; behavioural treatments; and the activities of the Reagan Foundation. The text integrates basic and clinical research findings, and provides evaluation of new approaches to therapy by world leaders in the field. The potential benefit for Alzheimer patients and families resulting from these research programmes, from molecular biology to clinical pharmacology, is reviewed and evaluated.

Product Details

ISBN-13:	9781461286608
Publisher:	Birkhäuser Boston
Publication date:	06/29/2012
Series:	Advances in Alzheimer Disease Therapy
Edition description:	1997
Pages:	614
Product dimensions:	6.10(w) x 9.25(h) x 0.05(d)

About the Author

Becker, Robert E. (Southern Illinois Univ); Giacobini, Ezio

The contributors represent the specialties of Alzheimer's disease research, neurology, neuroscience, pathology, psychiatry, geriatrics, cellular physiology, molecular biology, pharmacology, immunobiology, biochemistry, chemistry, and neuropathology. Most are from academic hospitals, universities, research institutes, and pharmaceutical companies in the U.S., the U.K, Canada, France, and nine other countries. Institutions prominently represented include Univ of Florence, Washington Univ, USC, UCSD, Univ of Geneva, Duke, McGill Univ, Univ of Indiana, Parke-Davis, NYU, Univ of Kentucky, UC-Irvine, UCLA, McMaster, Merck Research Labs, Johns Hopkins, Stanford, Northwestern, Loyola, Southern Illinois Univ, and R.J. Reynolds.

Table of Contents

I. Pathological Basis of Therapy in Alzheimer’s Disease.- Criteria for the Diagnosis of Alzheimer’s Disease.- Neuropathology Of Alzheimer’s Disease.- Processing of Amyloid, Cytoskeletal Damage and Apolipoproteins.- Cell Death: Excitotoxins, Apoptosis And Hypometabolism.- Neurotrophins, Growth Factors and Neuroprotectors.- Animal Models.- II. The Cholinergic System in Brain.- Treatment of Alzheimer Disease.- Cholinesterase Inhibitors in Alzheimer Disease Treatment.- III. Nicotinic and Muscarinic Cholinergic Agonists.- Nicotinic Agonists.- Muscarinic Agonists and Antagonists.- The Potential of Antioxidant Therapy.- The Potential for Anti-Inflammatory Therapy.- IV. Development of New Therapies in Alzheimer Disease.- Design of Clinical Trials.- Advances in Assessment.- SPECT and PET.- Potential Markers of Disease Progression and Drug Efficacy in Alzheimer’s Disease.- Treatment of Behavioral and Psychosocial Disturbances.- V. Social Issue in Alzheimer Disease.- Legal and Ethical Issues.- Socio-Economic As pects of Alzheimer Disease Treatment.- International Harmonization of Drug Guidelines.- Research Priorities in Alzheimer Disease Treatment — An International Perspective.- Author Index.

Editorial Reviews

2 Stars from Doody

This book presents an international review of topics concerning Alzheimer's disease. Its purpose is to provide reviews of current advances in Alzheimer's disease research. The primary audience for this book is those interested in current research in Alzheimer's disease. This book features a variety of areas from molecular biology, approaches to pharmacologic treatment, assessment, clinical approach to diagnosis and management, and ethical concerns. This book represents a truly international perspective. The very short chapters are concise summaries of the approaches to Alzheimer's disease in many different areas. Some represent a synthesis of ideas; others summarize current research. The book appeals mainly to specialists working in the area of Alzheimer's disease; it is clearly not useful as a textbook.

David O. Staats

Reviewer: David O. Staats, MD (University of Oklahoma Health Sciences Center)
Description: This book presents an international review of topics concerning Alzheimer's disease.
Purpose: Its purpose is to provide reviews of current advances in Alzheimer's disease research.
Audience: The primary audience for this book is those interested in current research in Alzheimer's disease.
Features: This book features a variety of areas from molecular biology, approaches to pharmacologic treatment, assessment, clinical approach to diagnosis and management, and ethical concerns.
Assessment: This book represents a truly international perspective. The very short chapters are concise summaries of the approaches to Alzheimer's disease in many different areas. Some represent a synthesis of ideas; others summarize current research. The book appeals mainly to specialists working in the area of Alzheimer's disease; it is clearly not useful as a textbook.

Doody's Review Service