Amyloid Protein Precursor in Development, Aging and Alzheimer's Disease

by C.L. Masters (Editor), K. Beyreuther (Editor), Marc Trillet (Editor)

Overview

This book summarizes the last ten years' research on Alzheimer's disease. Genetic mutations in the gene which codes for amyloid precursor protein (APP) have now been shown to cause Alzheimer's disease in some families. Other genetic loci are now being discovered which relate to Alzheimer's disease in some families. Understanding the normal structure and function of the APP gene product will eventually provide avenues for developing specific therapeutic strategies targeted at the amyloid deposition in the Alzheimer's disease brain. Drugs which can inhibit or dissolve the amyloid, affect the synthesis and proteolysis of APP, or which regulate the activity of the APP gene all hold the promise of eventually yielding an effective treatment for Alzheimer's disease.

Product Details

ISBN-13:	9783662011379
Publisher:	Springer Berlin Heidelberg
Publication date:	08/29/2012
Series:	Research and Perspectives in Alzheimer's Disease
Edition description:	Softcover reprint of the original 1st ed. 1994
Pages:	257
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

Strategic Thoughts on the Alzheimer’s Disease Amyloid Protein Precursor: The Way Forward.- Drosophila Appl Gene and APPL Protein: A Model System to Study the Function of the APP Protein Family.- Amyloid—A4 of Alzheimer’s Disease: Structural Requirements for Folding and Aggregation.- Production of Amyloid— Protein from Normal and Mutated Amyloid ² Protein Precursors.- Mechanism of Cerebral Amyloidosis in Alzheimer’s Disease.- Effects of Fragments of the—-Amyloid Protein on Hippocampal Neurons in Young and Aged Rats: An Electrophysiological Study.- The Role of the Extracellular Matrix in Regulating the Function of the Amyloid Protein Precursor of Alzheimer’s Disease.- Studies of the Amyloid Precursor Protein (APP) in Brain: Regulation of APP-Ligand Binding.- The Biological Function of Amyloid—/A4 Protein Precursor.- Processing of Alzheimer A?-Amyloid Precursor Protein: Cell Biology, Regulation, and Role in Alzheimer’s Disease.- Studies of APP Biology: Analysis of APP Secretion and Characterization of an APP Homologue, APLP2.- Transmembrane APP is Distributed into Two Pools and Associated with Polymerized Cytoskeleton.- Isolation and Characterisation of Novel Metalloproteases from Embryonic Mouse Hippocampus.- A Transgenic Mouse Model of Alzheimer’s Disease.- Amyloid in Alzheimer’s Disease and Animal Models.- The Roles of Zinc and Copper in the Function and Metabolism of the Amyloid Protein Precursor Superfamily.- The Diverse Molecular Nature of Inherited Alzheimer’s Disease.- Genetic Variability and Alzheimer’s Disease.- Genetic Defects in Early Onset Alzheimer’s Disease and Related Disorders.- APP Gene Mutations in Familial Alzheimer’s Disease in Sweden.- Aging, Energy and Alzheimer’s Disease.- Molecular Biology and Genetics of HumanPrion Diseases and PrP Amyloid Plaque Formation.