Table of Contents
Contributors ix
Preface xvii
Acknowledgments xix
Section I Introductory Chapters
Chapter 1 Overview Shu Chien 3
Chapter 2 Perspectives of Biomechanics Yuan-Cheng B. Fung Wei Huang 13
Section II Cardiovascular Bioengineering
Chapter 3 Cardiac Electromechanics in the Healthy Heart Roy C. P. Kerckhoffs Andrew D. McCulloch 37
Chapter 4 Cardiac Biomechanics and Disease Jeffrey H. Omens 53
Chapter 5 Bioengineering Solutions for the Treatment of Heart Failure John T. Watson Shu Chien 69
Chapter 6 Molecular Basis of Modulation of Vascular Functions by Mechanical Forces Shu Chien 79
Chapter 7 Autoregulation of Blood Flow: Examining the Process of Scientific Discovery Paul C. Johnson 99
Section III Blood Cell Bioengineering
Chapter 8 Molecular Basis of Cell and Membrane Mechanics Lanping Amy Sung 117
Chapter 9 Cell Activation in the Circulation: The Auto-Digestion Hypothesis Geert W. Schmid-Schonbein 131
Chapter 10 Blood Substitutes and the Design of Oxygen Non-Carrying and Carrying Fluids Marcos Intaglietta 149
Section IV Respiratory-Renal Bioengineering
Chapter 11 Analysis of Human Pulmonary Circulation: A Bioengineering Approach Wei Huang Michael R. T. Yen Qinlian Zhou 163
Chapter 12 Pulmonary Gas Exchange Peter D. Wagner 181
Chapter 13 Engineering Approaches to Understanding the Kidney Scott C. Thomson 209
Section V Tissue Engineering and Regenerative Medicine
Chapter 14 Skeletal Muscle Tissue Bioengineering Richard L. Lieber Samuel R. Ward 225
Chapter 15 Multi-Scale Biomechanics of Articular Cartilage Won C. Bae Robert L. Sah 243
Chapter 16 Design and Development of an In Vivo Force-Sensing Knee Prosthesis Darryl D. D'Lima Peter C. Y.Chen 261
Chapter 17 The Implantable Glucose Sensor in Diabetes: A Bioengineering Case Study David A. Gough 279
Chapter 18 Stem Cells in Regenerative Medicine Shu Chien Lawrence S. B. Goldstein 291
Section VI Nanoscience and Nanotechnology
Chapter 19 Engineering Compounds Targeted to Vascular Zip Codes Erkki Ruoslahti 313
Chapter 20 The Structure of the Central Nervous System and Nanoengineering Approaches for Studying and Repairing It Gabriel A. Silva 327
Chapter 21 Cellular Biophotonics: Laser Scissors (Ablation) Michael W. Berns 353
Chapter 22 Microelectronic Arrays: Applications from DNA Hybridization Diagnostics to Directed Self-Assembly Nanofabrication Michael J. Heller Dietrich Dehlinger 369
Section VII Genomic Engineering and Systems Biology
Chapter 23 Systems Biology: A Four-Step Process Jennifer L. Reed Bernhard O. Palsson 387
Chapter 24 Bioinformatics and Systems Biology: Obtaining the Design Principles of Living Systems Shankar Subramaniam 401
Chapter 25 Synthetic Biology: Bioengineering at the Genomic Level Natalie Ostroff Mike Ferry Scott Cookson Tracy Johnson Jeff Hasty 427
Chapter 26 Network Genomics 453 Trey Ideker
Chapter 27 Genomes, Genomic Technologies and Medicine Xiaohua Huang 473
Section VIII Socio-Economical Aspects of Bioengineering
Chapter 28 Ethics for Bioengineers Michael Kalichman 489
Chapter 29 Opportunities and Challenges in Bioengineering Entrepreneurship Jen-Shih Lee 507
Chapter 30 How to Move Medical Devices from Bench to Bedside Paul Citron 521
Index 533
