Analytical Profiles Of Selected Medicinal Plants

by K K Bhutani, Birinder Pal Singh

Overview

Since ancient times, herbals have been the mainstay of folkloric medicines all around the world. Traditional systems of medicines around the world have integrated phytotherapy into their doctrine. However, the use of phytotherapy fails to fit into the efficacy and safety criteria established for contemporary medicine. High quality standards products are needed to allow the patient to make safe use of phytotherapeutic products. Standardization of herbal medicines helps develop a set of standards or intrinsic characteristics that carry an assurance of quality and reproducibility Since ancient times, herbals have been the mainstay of folkloric medicines all around the world. Traditional systems of medicines around the world have integrated phytotherapy into their doctrine. However, the use of phytotherapy fails to fit into the efficacy and safety criteria established for contemporary medicine. High quality standards products are needed to allow the patient to make safe use of phytotherapeutic products. Standardization of herbal medicines helps develop a set of standards or intrinsic characteristics that carry an assurance of quality and reproducibility of herbal preparation. Specific standards are worked out by experimentation, which would lead to the process of stipulating an individuality exhibited by the particular herbal medicine. Hence standardization is a tool in the quality control process The present book is a small step towards this goal. In this book, standardization and identification of the marker compounds in medicinal plants have been carried out using analytical techniques starting from basic and cost effective to highly sophisticated ones. Although, HPLC is considered more specific and better technique, TLC still remains a versatile and valuable analytical tool due to its high-throughput and cost-effectiveness for plant analysis. Several studies have indicated a poor quality control and batch to batch variations in the marketed traditional preparations thereby necessitating the use of these analytical tools for quality control. LC-MS, a technique that combines the physical separation capabilities of liquid chromatography with the mass analysis capabilities of mass spectrometry (MS) and is known for its high sensitivity, has also found extensive usage in fingerprinting of plant extracts, but has not been used much for the quality control purpose of traditional medicines or herbal products. We believe that the importance of QNMR in analysis of botanicals will grow immensely as it does not require the pure reference markers for the preparation of calibration curves for the purpose of quantitative analysis. This book includes quantitative analysis of markers in 20 plants with TLC, 43 plants with HPLC, 29 plants with LC-MS and 8 plants using QNMR.

Product Details

ISBN-13:	9789387813595
Publisher:	Arts & Science Academic Publishing
Publication date:	06/30/2017
Sold by:	Barnes & Noble
Format:	eBook
Pages:	260
File size:	8 MB

About the Author

Dr. Kamlesh Kumar Bhutani is a Professor and Head of the Department of Natural Products at National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar and is also Director of this premier Institute. He has more than forty years of academic and industrial research experience, around 160 research papers in high impact factor peer reviewed international Journals of repute, ten books, eight book chapters, two documentaries, and twenty six reviews. He has made enormous contributions in drug discovery and development and rationalization of natural products for therapeutic usage in general and specifically in the areas of life style diseases (obesity, hyperlipidemia and diabetes), inflammation (TNF-a, IL-1b), protozoan diseases (leishmaniasis, amoebiasis etc.), viral infections (HIV), microbicides, immunomodulators and standardization of Ayurvedic Medicines and Herbal Medicinal Products. He has guided eighteen PhD and 90 M.S. (Pharm.) students. He has developed more than eighty monographs for quality standards of Indian medicinal plants for Indian Council of Medical Research and Ayurvedic Pharmacopoeia of India. He has been project coordinator/principal investigator for more than three dozen major projects sponsored by national and international agencies, and big pharmaceutical industries and is a key member of several expert groups.



Dr. Inder Pal Singh is a Professor of Natural Products Chemistry at National Institute of Pharmaceutical Education and Research (NIPER), SAS Nagar. He has twenty five years of research experience. His research interests include isolation of bioactive molecules from natural sources, biomimetic synthesis of bioactive natural products and their analogs for therapeutic areas such as HIV, cancer, and leishmaniasis, and standardization of herbal/Ayurvedic formulations using various analytical techniques such as HPTLC, HPLC, and quantitative NMR (qNMR). He has guided nine PhD and 53 M.S. (Pharm.) students. He has authored more than 100 peer reviewed publications and one book on stereochemistry.