Animal Cells as Bioreactors

by Terence Cartwright

Overview

This book covers all aspects of the new technologies needed to turn animal cells into an acceptable and cost-effective tool for drug production. This includes modifying them genetically so that they produce the right product in high yield, getting them to grow reproducibly on an industrial scale, and extracting the required product from them. It also covers biological safety issues, and the verification of the chemical and biological nature of the protein drug produced. The work covers the latest developments in all of these areas and how they all need to be integrated for the design of an effective biotechnological production process.

Product Details

ISBN-13:	9780521103107
Publisher:	Cambridge University Press
Publication date:	03/19/2009
Series:	Cambridge Studies in Biotechnology , #11
Pages:	196
Product dimensions:	5.98(w) x 9.02(h) x 0.47(d)

Table of Contents

1. Introducing the animal cell as a bioreactor; 2. Yield of recombinant product: engineering cells for maximum expression; 3. The generation of biomass, medium design for animal cell culture, fermenter design for animal cell culture, suspension cultures, immobilized cells, process control; 4. Adjusting cellular metabolism for optimum product yield; 5. Downstream processing; 6. Regulatory aspects of using cells as bioreactors, viral contamination of animal cell derived pharmaceuticals; 7. Overview and conclusions; References; Index.

Editorial Reviews

"...a concise review and summary of past problems, current status, and future directions of the methodology of animal cell culture at the center of the production line for the biotechnology industry...this well-organized, clearly writtenm and extensively referenced work will serve as an introduction for the novice and an overall review for the experienced." A.D. Gounaris, Choice

"This book covers all aspects of the new biotechnological methods needed to turn animal cells into an acceptable and cost effective tool for drug production. It is well-written and easy to read...The author demonstrates how far the field has come in the last ten years and provides a useful reference work for all budding biotechnologists." Wendie Norris, British Society for Developmental Biology Newsletter

"The book is easy to follow and it serves as a good introduction to the biologists who wishes to start using animal cell biotechnology. Animal Cells as Bioreactor is a well written and documented text. The book contains much information and so will be useful equally as a textbook and a reference book to students, teachers and scientists who are active in biotechnology research and development." Canadian Society of Microbiologists Newsletter

From the Publisher