Animal Models of Diabetes: Frontiers in Research / Edition 2

by Eleazar Shafrir

Overview

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new knowledge on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Product Details

ISBN-13:	9780367389253
Publisher:	Taylor & Francis
Publication date:	10/18/2019
Edition description:	2nd ed.
Pages:	384
Product dimensions:	6.12(w) x 9.19(h) x (d)

Table of Contents

Chapter 1 Rat Models of Type 1 Diabetes: Genetics, Environment, and Autoimmunity John P. Mordes Philippe Poussier Aldo A. Rossini Elizabeth P. Blankenhorn Dale L. Greiner 1

Chapter 2 The NOD Mouse and Its Related Strains Hidenori Taniguchi Susumu Makino Hiroshi Ikegami 41

Chapter 3 Obesity/Diabetes in Mice with Mutations in Leptin or Leptin Receptor Genes Streamson Chua, Jr. Lieselotte Herberg Edward H. Leiter 61

Chapter 4 The Zucker Diabetic Fatty (ZDF) Rat-Lessons from a Leptin Receptor Defect Diabetic Model Richard G. Peterson 103

Chapter 5 The Goto-Kakizaki Rat Claes-Göran Östenson 119

Chapter 6 The New Zealand Obese Mouse: Polygenic Model of Obesity, Glucose Intolerance, and the Metabolic Syndrome Barbara C. Fam Sofianos Andrikopoulos 139

Chapter 7 The JCR:LA-cp Rat: Animal Model of the Metabolic Syndrome Exhibiting Micro- and Macrovascular Disease James C. Russell Sandra E. Kelly Spencer D. Proctor 159

Chapter 8 The SHROB (Koletsky) Rat as a Model for Metabolic Syndrome Richard J. Koletsky Rodney A. Velliquette Paul Ernsberger 185

Chapter 9 OLETF Rats: Model for the Metabolic Syndrome and Diabetic Nephropathy in Humans Kazuya Kawano 209

Chapter 10 Neonatally Streptozotocin-Induced (n-STZ) Diabetic Rats: A Family of Type 2 Diabetes Models B. Portha J. Movassat C. Cuzin-Tourrel D. Bailbe M. H. Giroix P. Serradas M. Dolz M. Kergoat 223

Chapter 11 The Rhesus Monkey (Macaca mulatto) Manifests All Features of Human Type 2 Diabetes Barbara C. Hansen Xenia T. Tigno 251

Chapter 12 Pigs in Diabetes Research, with Special Focus on Type 2 Diabetes Research Marianne O. Larsen Bidda Rolin 271

Chapter 13 Psammomys Obesus: Nutritionally Induced Insulin Resistance, Diabetes, and Beta Cell Loss Ehud Ziv Rony Kalman Eleazar Shafrir 289

Chapter 14 The Spontaneously Diabetic Torii (SDT) Rat with Retinopathy Lesions Resembling Those of Humans Masami Shinohara Taku Masuyama Akihiro Kakehashi 311

Chapter 15 Cohen Diabetic Rat Sarah Weksler-Zangen Esther Orlanski David H. Zangen 323

Chapter 16 KK and KKA^y Mice: Models of Type 2 Diabetes with Obesity Shigehisa Taketomi 335

Chapter 17 Animal Models to Study Obesity and Type 2 Diabetes Induced by Diet Tamer Coskun Yanyun Chen Dana Sindelar Mark Heiman 349

Index 359