Applied Electrospray Mass Spectrometry: Practical Spectroscopy Series Volume 32

by Birendra N. Pramanik (Editor), A.K. Ganguly (Editor), Michael L. Gross (Editor)

Overview

Discussing strategies to determine the structure and machanisms of numerous compound classics, this book covers new chemical and elctrophoretic techniques for rapid sample preconcentration and separation. It summarizes breakthroughs in the theory and instrumentation of electrospray mass spectrometry in pharmaceutical and biomedical applications, provides practical examples for the characterization of peptides, proteins, and glycoproteins, includes applications in proteomics, combinatorial chemistry, and drug characterization. Topics include chemical and electrophoretic techniques for rapid sample preconcentration and separation, screening processes for proteins from libraries of compounds, protein folding and dynamics, and more.

Product Details

ISBN-13:	9781135560430
Publisher:	CRC Press
Publication date:	02/28/2002
Series:	Practical Spectroscopy
Sold by:	Barnes & Noble
Format:	eBook
Pages:	446
File size:	6 MB

About the Author

Birendra N. Pramanik (Edited by) , A. K. Ganguly (Edited by) , Michael L. Gross (Edited by)

Table of Contents

Historical review/principles/instrumentation; nano-spray ESI development - LC/MS, CE/MS application; antibiotics/pharmaceuticals; pharmacokinetics/drug metabolism; proteins/peptides; glyco-proteins; proteomics/bioinformatics; noncovalent complexes;H/D exchange in solution; clinical biomedical application - micro-flow ESI.

Editorial Reviews

Focusing on the application of mass spectrometric analysis to pharmaceutical, peptide, and protein chemistry, this volume contains 11 articles written by contributors from industry and academia. The volume begins with a historical review of the ESI technique including its principles and instrumentation, a description of nanospray development, and applications in macromolecules. Chapters that follow address applications of small molecules; peptides and proteins; noncovalent complexes; special topics in protein folding and unfolding; and clinical and biomedical applications. A number of chapters should be of great interest to scientists in the pharmaceutical industries. Annotation c. Book News, Inc., Portland, OR (booknews.com)

"…summarizes the most recent breakthroughs in the theory and instrumentation of electrospray mass spectrometry."
-International Journal of Environmental Analytical Chemistry

"…excellent."
-Journal of the American Chemical Society

"…a full and clear discussion…"…covers a broad range of the modern applications of ESI-MS….well-written and structured."
-Journal of Analytical Atomic Spectrometry

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