Approaches to Design and Synthesis of Antiparasitic Drugs

by N. Anand (Editor), S. Sharma? (Editor)

Overview

This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Product Details

ISBN-13:	9780080527529
Publisher:	Elsevier Science
Publication date:	07/10/1997
Series:	ISSN , #25
Sold by:	Barnes & Noble
Format:	eBook
Pages:	510
File size:	14 MB
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Table of Contents

1. INTRODUCTION. Chapter 1. Parasitic diseases: An overview. II. ANTIHELMINTHIC AGENTS. Chapter 2. Biochemical targets for anthelminthic activity. Chapter 3. Natural products. Chapter 4. Organometallics. Chapter 5. Piperazines. Chapter 6. Tetrahydropyrimidines. Chapter 7. Imidazothiozoles. Chapter 8. Benzimidazoles. Chapter 9. Salicylanilides. Chapter 10. Nitroaryl compounds. Chapter 11. Tetrahydroquinolines and isoquinolines. Chapter 12. Miscellaneous anthelminthics. III. ANTIPROTOZOAL AGENTS. Chapter 13. Biochemical targets for antiprotozoal activity. Chapter 14. Natural products. Chapter 15. Organometallics. Chapter 16. Quinolines. Chapter 17. Nitroheterocycles. Chapter 18. Antifolates. Chapter 19. Bisamidines. Chapter 20. Haloacetamides. Chapter 21. Miscellaneous antiprotozoals.

Editorial Reviews

from:J. L. Vennerstrom
"...This book is well organised in a format likely to appeal to a medicinal chemist. One of it's strengths is that it provides a useful description of the synthesis of antiparasitic agents in a singly volume." —Jounal of Medicinal Chemistry Vol. 41, No. 16

From the Publisher