Aspartic Proteinases: Structure, Function, Biology, and Biomedical Implications / Edition 1

by Kenji Takahashi

Overview

The 5th International Conference on Aspartic Proteinases was held on September 19 through 24, 1993, at Naito Museum of Pharmaceutical Science and Industry, Kawashima­ cho, Gifu Prefecture, Japan, about 15 miles northwest of Nagoya City. About 100 scientists attended the conference, including 52 from 14 countries outside Japan, and 32 papers were presented by invited speakers, and 58 papers as posters. The purpose of this conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic proteinases, and this book is a collec­ tion of nearly all the papers presented at the meeting. Aspartic proteinases belong to one of the four major classes of proteinases, the others being serine, cysteine, and metalloproteinases, and are so called since they have two catalytic aspartic acid residues in common in their active sites. Most of them are optimally active at acidic pH, hence the long-used name "acid proteinases," which, indeed, was the major title of the first conference of this series. However, some of them are active at around neutral pH, indicating their physiological roles in a wider range of pH than hitherto considered.

Product Details

ISBN-13:	9780306448300
Publisher:	Springer US
Publication date:	08/31/1995
Series:	Advances in Experimental Medicine and Biology , #362
Edition description:	1995
Pages:	629
Product dimensions:	7.01(w) x 10.00(h) x 0.05(d)

Table of Contents

Gastric Aspartic Proteinases: Plenary Lectures.- Gastric Aspartic Proteinases: Poster Reports.- Non-Gastric Aspartic Proteinases: Plenary Lectures.- Non-Gastric Aspartic Proteinases: Poster Reports.- Retroviral Aspartic Proteinases: Plenary Lectures.- Retroviral Aspartic Proteinases: Poster Reports.- Microbial Aspartic Proteinases: Plenary Lectures.- Microbial Aspartic Proteinases: Poster Reports.- Author Index.

Editorial Reviews

Proceedings of the Fifth International Conference on Aspartic Proteinases, held in Gifu, Japan, September 1993. The purpose of the conference was to present and discuss new information on the structure, function, and biology, and related topics, including biomedical implications, of aspartic proteinases. The papers (plenary and poster) are grouped into four categories, i.e., gastric, non- gastric, retroviral, and microbial aspartic proteinases. A few of the topics: comparison of the active site specificity of the aspartic proteinases based on a systematic series of peptide substrates; discovery of inhibitors of human renin with high oral bioavailability; and inhibitor-resistant mutants of the HIV-1 aspartic protease. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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