Aspirin and Related Drugs / Edition 1

by Kim D. Rainsford

Overview

Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin.

Highlighting the historical evolution of the salicylates and the commercial development of aspirin, the book reviews the pharmacokinetics of the salicylates, ibuprofen, and paracetamol as a basis for understanding the biodisposition of these analgesic drugs. Leading specialists discuss the therapeutic role of aspirin in the prevention and treatment of thrombo-embolic diseases, its place along with non-acetylated salicylates in the treatment of rheumatic diseases and plain, and the potential applications for aspirin and related drugs as prophylactics for colon cancer, Alzheimer's disease, and vascular dementia. They also present comparisons with other drugs used to treat pain and inflammation.

With extensive data and literature covering a broad field, this is the definitive reference on the actions and applications of aspirin, salicylates, and related drugs. Physicians, pharmacists, pharmacologists, toxicologists, and chemists will find this resource useful in their daily work. It will also be valuable to pharmaceutical companies and researchers in the development of newer agents and novel applications.

Product Details

ISBN-13:	9780367393656
Publisher:	Taylor & Francis
Publication date:	06/19/2019
Pages:	804
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

History and Development of the Salicylates. The Industrial History of Analgesics: The Evolution of Analgesics and Antipyretics. Occurrence, Properties and Synthetic Developments of the Salicylates. Pharmacokinetics and Metabolism of the Salicylates. Metabolism and Pharmacokinetics of Ibuprofen. Pharmacokinetics and Metabolism of Paracetamol (Acetaminophen). Pharmacology and Biochemistry of Salicylates and Related Drugs. Side-effects and Toxicology of the Salicylates. Reye's Syndrome and Aspirin. Salicylates in the Treatment of Acute Pain. Acetysalicylic Acid for the Prevention and Treatment of Thromboembolic Diseases. Use of Salicylates in Rheumatic and Related Conditions. Aspirin and NSAIDs in the Prevention of Cancer, Alzheimer's Disease and other Novel Therapeutic Actions.

Editorial Reviews

Reviewer: Thomas L. Pazdernik, PhD (University of Kansas Medical Center)
Description: Professor Rainsford provides, in this edited book, updates and expansion of information from a 1984 book that he authored entitled Aspirin and the Salicylates. This book contains almost everything you would want to know about aspirin and related compounds.
Purpose: His goal was to provide both a historical as well as a current comprehensive account on aspirin and related compounds. This is a thorough and excellent resource, but I would have liked to have seen a separate chapter on cyclooxygenase-2 (COX-2) inhibitors.
Audience: This is an excellent resource for those interested in the historical development of salicylates and related compounds as therapeutic agents, the current development of salicylate-related drugs, or the current therapeutic use of salicylate-related agents.
Features: The preface is followed by a list of useful books on aspirin and salicylates as well as important review articles and common abbreviations and nomenclature used throughout the book. The text is preceded by interesting plates that illustrate scenes and artifacts related to the development of marketing of aspirin since its introduction over a century ago. The first chapter provides an excellent history, including historical photographs, on the development of salicylates whereas the second chapter deals with the evolution of analgesic and antipyretics. The third chapter deals with the natural sources and synthetic development of salicylates as well as their physiochemical properties. A series of chapters discuss the pharmacokinetics of salicylates, ibuprofen, and acetaminophen. The pharmacodynamics and toxicology of salicylates is given in chapters 7 and 8, respectively. Chapter 9 is devoted to the relationship between Reye's syndrome and aspirin use. The remaining chapters focus on the therapeutic use of salicylates and/or related compounds in the treatment of pain, prevention and treatment of thrombolytic diseases, treatment of rheumatic and related disorders, and finally in the prevention of cancer, Alzheimer's disease, and other novel therapeutic actions.
Assessment: It is interesting that after more than a century aspirin is still the "gold standard" for analgesics, antipyretics, anti-inflammatories and thrombolytic drugs. This has recently been brought to the attention of the public with reports of increased cardiovascular events in patients on selective COX-2 inhibitors and naproxen.

Doody's Review Service