Biochemistry and Molecular Biology of Antimicrobial Drug Action / Edition 6

by Trevor J. Franklin, George Alan Snow

Overview

Preface to the sixth edition x 1 THE DEVELOPMENT OF ANTIMICROBIAL AGENTS, PAST, PRESENT AND FUTURE 1 1. 1 The social and economic importance of antimicrobial agents 1 1. 2 All outhne of the historical development of antimicrobial agents 2 1. 3 Reasons for studying the biochemistry and molecular biology of antimicrobial compounds 9 1. 4 Uncovering the molecular basis of antimicrobial action iO 1. 5 Current trends in the discovery of antimicrobial drugs 14 1. 6 . Scope and layout of the book 15 2 VULNERABLE SHIELDS—THE CELL WALLS OF BACTERIA AND FUNGI 17 2. 1 Functions of the ceU wall 17 2. 2 . Structure of the bacterial wall 17 2. 3 Structure and biosynthesis of peptidoglycan 22 2. 4 Antibiotics that inhibit peptidoglycan biosynthesis 29 2. 5 Drugs that interfere with the biosynthesis of the cell wall of mycobacteria 39 2. 6 The fungal cell wall as a target for antifungal drugs 41 3 ANTIMICROBIAL AGENTS AND CELL MEMBRANES 47 3. 1 Microbe killers: antiseptics and disinfectants 47 3. 2 Cationic peptide antibiotics 52 3. 3 lonophoric antibiotics 54 3. 4 Antifungal agents that interfere with the function and biosynthesis of membrane sterols 59 4 INHIBITORS OF NUCLEIC ACID BIOSYNTHESIS 65 4. 1 Compounds affecting the biosynthesis and utilization of nucleotide precursors 66 4. 2 Nucleoside analogues 70 4. 3 Inhibitors of the reverse transcriptase of the human immunodeficiency virus 72 4. 4 Antibacterial inhibitors of topoisomerases 75 4.

Product Details

ISBN-13:	9780387225548
Publisher:	Springer US
Publication date:	03/03/2005
Edition description:	6th ed. 2005
Pages:	182
Product dimensions:	7.01(w) x 10.00(h) x 0.03(d)

Table of Contents

The development of antimicrobial agents, past, present and future.- Vulnerable shields—the cell walls of bacteria and fungi.- Antimicrobial agents and cell membranes.- Inhibitors of nucleic acid biosynthesis.- Inhibitors of protein biosynthesis.- Antimicrobial drugs with other modes of action.- Attack and defense: drug transport across cell walls and membranes.- The genetic basis of resistance to antimicrobial drugs.- Biochemical mechanisms of resistance to antimicrobial drugs.

Editorial Reviews

Covers medically important antimicrobial compounds, as well as those not currently in use medically but which are valuable as research tools in biochemistry. This fifth edition concentrates on the action of compounds in clinical use against micro-organisms, and reflects advances in molecular biology, with new chapters on molecular genetics and biochemistry of antimicrobial drug resistance. Of interest to medical and biological sciences students, and researchers in drug action and development. Formerly titled . Snow was previously with Zeneca Pharmaceuticals. Franklin is a scientific advisor to FibroGen Inc. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

From the reviews of the sixth edition:

"This sixth edition builds on the successful formula of its predecessors with an accessible small format, clear diagrams and illustrations, key antibiotic structures and an engaging explanatory text. … the great strength ... is that it has managed to convey the essentials of the topic without … expanding in girth at each edition. … this book remains the first port of call for those requiring an overview of the topic or seeking a starting point for more in-depth information on an unfamiliar antimicrobial." (Jonathan H Cove, British Toxicology Society Newsletter, Winter, 2005)

From the Publisher