5
1
9780470570951
Biochemistry / Edition 4 available in Hardcover
- ISBN-10:
- 0470570954
- ISBN-13:
- 9780470570951
- Pub. Date:
- 12/01/2010
- Publisher:
- Wiley
$364.75
Current price is , Original price is $364.75. You
Buy New
$364.75Buy Used
$58.41
$364.75
-
SHIP THIS ITEM— Not Eligible for Free Shipping$58.41
-
SHIP THIS ITEM
Temporarily Out of Stock Online
Please check back later for updated availability.
-
364.75
In Stock
Overview
Since its first edition in 1990, over 250,000 students have used Biochemistry by Donald Voet of the University of Pennsylvania and Judith Voet of Swarthmore College. It has been translated into six languages (Japanese, German, French, Spanish, Italian, and Czech) and is regarded around the world as the standard in its field.
Product Details
ISBN-13: | 9780470570951 |
---|---|
Publisher: | Wiley |
Publication date: | 12/01/2010 |
Edition description: | 4th ed. |
Pages: | 1520 |
Sales rank: | 514,321 |
Product dimensions: | 8.90(w) x 11.10(h) x 2.20(d) |
About the Author
Donald Voet received a Ph.D. in chemistry from Harvard University and did postdoctoral research in the Biology Department at MIT. Don took up a faculty position in the department of chemistry at the University of Pennsylvania, upon completing his postdoctoral work. He has been a visiting scholar at Oxford University, the University of California San Diego, and the Weismann Institute of Science in Israel.
Judith Voet received her Ph.D. from Brandeis University and did postdoctoral research at the University of Pennsylvania, Haverford College and the Fox Chase Cancer Center. She taught at the University of Delaware before moving to Swarthmore College. Together with Don Voet, she is Co-Editor-in-Chief of the journal Biochemistry and Molecular Biology Education.
Table of Contents
Part I | Introduction and Background | 1 |
Chapter 1 | Life | 3 |
1. | Prokaryotes | 3 |
2. | Eukaryotes | 7 |
3. | Biochemistry: A Prologue | 14 |
4. | Genetics: A Review | 19 |
5. | The Origin of Life | 28 |
6. | The Biochemical Literature | 34 |
Chapter 2 | Aqueous Solutions | 39 |
1. | Properties of Water | 39 |
2. | Acids, Bases, and Buffers | 44 |
Chapter 3 | Thermodynamic Principles: A Review | 51 |
1. | First Law of Thermodynamics: Energy Is Conserved | 52 |
2. | Second Law of Thermodynamics: The Universe Tends toward Maximum Disorder | 53 |
3. | Free Energy: The Indicator of Spontaneity | 56 |
4. | Chemical Equilibria | 57 |
Appendix | Concentration Dependence of Free Energy | 60 |
Part II | Biomolecules | 63 |
Chapter 4 | Amino Acids | 65 |
1. | The Amino Acids of Proteins | 65 |
2. | Optical Activity | 71 |
3. | "Nonstandard" Amino Acids | 76 |
Chapter 5 | Nucleic Acids, Gene Expression, and Recombinant DNA Technology | 80 |
1. | Nucleotides and Nucleic Acids | 80 |
2. | DNA Is the Carrier of Genetic Information | 82 |
3. | Double Helical DNA | 85 |
4. | Gene Expression and Replication: An Overview | 92 |
5. | Molecular Cloning | 101 |
Chapter 6 | Techniques of Protein and Nucleic Acid Purification | 127 |
1. | Protein Isolation | 127 |
2. | Solubilities of Proteins | 131 |
3. | Chromatographic Separations | 133 |
4. | Electrophoresis | 144 |
5. | Ultracentrifugation | 151 |
6. | Nucleic Acid Fractionation | 155 |
Chapter 7 | Covalent Structures of Proteins and Nucleic Acids | 161 |
1. | Primary Structure Determination of Proteins | 162 |
2. | Nucleic Acid Sequencing | 175 |
3. | Chemical Evolution | 182 |
4. | Bioinformatics: An Introduction | 191 |
5. | Chemical Synthesis of Polypeptides | 203 |
6. | Chemical Synthesis of Oligonucleotides | 207 |
Chapter 8 | Three-Dimensional Structures of Proteins | 219 |
1. | Secondary Structure | 219 |
2. | Fibrous Proteins | 231 |
3. | Globular Proteins | 240 |
4. | Protein Stability | 258 |
5. | Quaternary Structure | 265 |
Appendix | Viewing Stereo Pictures | 269 |
Chapter 9 | Protein Folding, Dynamics, and Structural Evolution | 276 |
1. | Protein Folding: Theory and Experiment | 276 |
2. | Folding Accessory Proteins | 288 |
3. | Protein Structure Prediction and Design | 299 |
4. | Protein Dynamics | 302 |
5. | Conformational Diseases: Amyloids and Prions | 306 |
6. | Structural Evolution | 312 |
Chapter 10 | Hemoglobin: Protein Function in Microcosm | 320 |
1. | Hemoglobin Function | 320 |
2. | Structure and Mechanism | 327 |
3. | Abnormal Hemoglobins | 339 |
4. | Allosteric Regulation | 345 |
Appendix | Derivation of Symmetry Model Equations | 352 |
Chapter 11 | Sugars and Polysaccharides | 356 |
1. | Monosaccharides | 356 |
2. | Polysaccharides | 362 |
3. | Glycoproteins | 369 |
Chapter 12 | Lipids and Membranes | 382 |
1. | Lipid Classification | 382 |
2. | Properties of Lipid Aggregates | 389 |
3. | Biological Membranes | 394 |
4. | Membrane Assembly and protein Targeting | 414 |
5. | Lipoproteins | 439 |
Part III | Mechanisms of Enzyme Action | 457 |
Chapter 13 | Introduction to Enzymes | 459 |
1. | Historical Perspective | 459 |
2. | Substrate Specificity | 460 |
3. | Coenzymes | 463 |
4. | Regulation of Enzymatic Activity | 465 |
5. | A Primer of Enzyme Nomenclature | 470 |
Chapter 14 | Rates of Enzymatic Reactions | 472 |
1. | Chemical Kinetics | 473 |
2. | Enzyme Kinetics | 477 |
3. | Inhibition | 482 |
4. | Effects of pH | 486 |
5. | Bisubstrate Reactions | 487 |
Appendix | Derivations of Michaelis-Menten Equation Variants | 491 |
Chapter 15 | Enzymatic Catalysis | 496 |
1. | Catalytic Mechanisms | 496 |
2. | Lysozyme | 507 |
3. | Serine Proteases | 515 |
4. | Drug Design | 528 |
Part IV | Metabolism | 547 |
Chapter 16 | Introduction to Metabolism | 549 |
1. | Metabolic Pathways | 549 |
2. | Organic Reaction Mechanisms | 552 |
3. | Experimental Approaches to the Study of Metabolism | 559 |
4. | Thermodynamics of Phosphate Compounds | 566 |
5. | Oxidation-Reduction Reactions | 571 |
6. | Thermodynamics of Life | 574 |
Chapter 17 | Glycolysis | 581 |
1. | The Glycolytic Pathway | 582 |
2. | The Reactions of Glycolysis | 585 |
3. | Fermentation: The Anaerobic Fate of Pyruvate | 602 |
4. | Metabolic Regulation and Control | 607 |
5. | Metabolism of Hexoses Other than Glucose | 618 |
Chapter 18 | Glycogen Metabolism | 626 |
1. | Glycogen Breakdown | 626 |
2. | Glycogen Synthesis | 632 |
3. | Control of Glycogen Metabolism | 635 |
4. | Glycogen Storage Diseases | 651 |
Chapter 19 | Signal Transduction | 657 |
1. | Hormones | 657 |
2. | Heterotrimeric G Proteins | 673 |
3. | Tyrosine Kinase-Based Signaling | 683 |
4. | The Phosphoinositide Cascade | 707 |
Chapter 20 | Transport through Membranes | 726 |
1. | Thermodynamics of Transport | 726 |
2. | Kinetics and Mechanisms of Transport | 727 |
3. | ATP-Driven Active Transport | 738 |
4. | Ion Gradient-Driven Active Transport | 746 |
5. | Neurotransmission | 750 |
Chapter 21 | Citric Acid Cycle | 765 |
1. | Cycle Overview | 765 |
2. | Metabolic Sources of Acetyl-Coenzyme A | 768 |
3. | Enzymes of the Citric Acid Cycle | 781 |
4. | Regulation of the Citric Acid Cycle | 790 |
5. | The Amphibolic Nature of the Citric Acid Cycle | 792 |
Chapter 22 | Electron Transport and Oxidative Phosphorylation | 797 |
1. | The Mitochondrion | 798 |
2. | Electron Transport | 802 |
3. | Oxidative Phosphorylation | 820 |
4. | Control of ATP Production | 836 |
Chapter 23 | Other Pathways of Carbohydrate Metabolism | 843 |
1. | Gluconeogenesis | 843 |
2. | The Glyoxylate Cycle | 850 |
3. | Biosynthesis of Oligosaccharides and Glycoproteins | 852 |
4. | The Pentose Phosphate Pathway | 862 |
Chapter 24 | Photosynthesis | 871 |
1. | Chloroplasts | 871 |
2. | Light Reactions | 873 |
3. | Dark Reactions | 896 |
Chapter 25 | Lipid Metabolism | 909 |
1. | Lipid Digestion, Absorption, and Transport | 909 |
2. | Fatty Acid Oxidation | 914 |
3. | Ketone Bodies | 928 |
4. | Fatty Acid Biosynthesis | 930 |
5. | Regulation of Fatty Acid Metabolism | 940 |
6. | Cholesterol Metabolism | 942 |
7. | Eicosanoid Metabolism: Prostaglandins, Prostacyclins, Thromboxanes, Leukotrienes, and Lipoxins | 959 |
8. | Phospholipid and Glycolipid Metabolism | 969 |
Chapter 26 | Amino Acid Metabolism | 985 |
1. | Amino Acid Deamination | 985 |
2. | The Urea Cycle | 991 |
3. | Metabolic Breakdown of Individual Amino Acids | 995 |
4. | Amino Acids as Biosynthetic Precursors | 1013 |
5. | Amino Acid Biosynthesis | 1030 |
6. | Nitrogen Fixation | 1044 |
Chapter 27 | Energy Metabolism: Integration and Organ Specialization | 1054 |
1. | Major Pathways and Strategies of Energy Metabolism: A Summary | 1054 |
2. | Organ Specialization | 1057 |
3. | Metabolic Homeostasis: Regulation of Appetite, Energy Expenditure, and Body Weight | 1061 |
4. | Metabolic Adaptation | 1065 |
Chapter 28 | Nucleotide Metabolism | 1069 |
1. | Synthesis of Purine Ribonucleotides | 1069 |
2. | Synthesis of Pyrimidine Ribonucleotides | 1076 |
3. | Formation of Deoxyribonucleotides | 1080 |
4. | Nucleotide Degradation | 1092 |
5. | Biosynthesis of Nucleotide Coenzymes | 1098 |
Part V | Expression and Transmission of Genetic Information | 1105 |
Chapter 29 | Nucleic Acid Structures | 1107 |
1. | Double Helical Structures | 1107 |
2. | Forces Stabilizing Nucleic Acid Structures | 1115 |
3. | Supercoiled DNA | 1122 |
Chapter 30 | DNA Replication, Repair, and Recombination | 1136 |
1. | DNA Replication: An Overview | 1136 |
2. | Enzymes of Replication | 1139 |
3. | Prokaryotic Replication | 1152 |
4. | Eukaryotic Replication | 1162 |
5. | Repair of DNA | 1173 |
6. | Recombination and Mobile Genetic Elements | 1184 |
7. | DNA Methylation and Trinucleotide Repeat Expansions | 1204 |
Chapter 31 | Transcription | 1216 |
1. | The Role of RNA in Protein Synthesis | 1216 |
2. | RNA Polymerase | 1221 |
3. | Control of Transcription in Prokaryotes | 1237 |
4. | Posttranscriptional Processing | 1254 |
Chapter 32 | Translation | 1285 |
1. | The Genetic Code | 1285 |
2. | Transfer RNA and Its Aminoacylation | 1292 |
3. | Ribosomes and Polypeptide Synthesis | 1309 |
4. | Control of Eukaryotic Translation | 1342 |
5. | Posttranslational Modification | 1347 |
6. | Protein Degradation | 1352 |
Chapter 33 | Viruses: Paradigms for Cellular Function | 1372 |
1. | Tobacco Mosaic Virus | 1374 |
2. | Icosahedral Viruses | 1379 |
3. | Bacteriophage [lambda] | 1390 |
4. | Influenza Virus | 1408 |
Chapter 34 | Eukaryotic Gene Expression | 1422 |
1. | Chromosome Structure | 1422 |
2. | Genomic Organization | 1432 |
3. | Control of Expression | 1446 |
4. | Cell Differentiation and Growth | 1482 |
Chapter 35 | Molecular Physiology | |
1. | Blood Clotting | |
2. | Immunity | |
3. | Motility: Muscles, Cilia, and Flagella | |
Index | 1527 |
From the B&N Reads Blog
Page 1 of