Bioinformatics : Sequence and Genome Analysis / Edition 2

by David Mount

Overview

As more species' genomes are sequenced, computational analysis of these data has become increasingly important. The second, entirely updated edition of this widely praised textbook provides a comprehensive and critical examination of the computational methods needed for analyzing DNA, RNA, and protein data, as well as genomes. The book has been rewritten to make it more accessible to a wider audience, including advanced undergraduate and graduate students. New features include chapter guides and explanatory information panels and glossary terms. New chapters in this second edition cover statistical analysis of sequence alignments, computer programming for bioinformatics, and data management and mining. Practically oriented problems at the ends of chapters enhance the value of the book as a teaching resource. The book also serves as an essential reference for professionals in molecular biology, pharmaceutical, and genome laboratories.

Product Details

ISBN-13:	9780879697129
Publisher:	Cold Spring Harbor Laboratory Press
Publication date:	08/16/2004
Series:	Textbook Series
Edition description:	Older Edition
Pages:	692
Product dimensions:	11.10(w) x 8.52(h) x 1.33(d)

About the Author

David W. Mount is Professor of Molecular and Cellular Biology, Professor of Biochemistry, and Professor of Ecology and Evolutionary Biology at the University of Arizona in Tucson. His broad-ranging research interests include sequence analysis and genomic databases, mechanisms of genetic recombination and radiation resistance in plants, as well as conservation genetics, molecular ecology, and molecular evolution. His book Bioinformatics: Sequence and Genome Analysis is based on a course he teaches at the University of Arizona.

Table of Contents

Preface
Chapter 1. Historical Introduction and Overview
Chapter 2. Collecting and Storing Sequences in the Laboratory
Chapter 3. Alignment of Pairs of Sequences
Chapter 4. Introduction to Probability and Statistical Analysis of Sequence Alignments
Chapter 5. Multiple Sequence Alignment
Chapter 6. Sequence Database Searching for Similar Sequences
Chapter 7. Phylogenetic Prediction
Chapter 8. Prediction of RNA Secondary Structure
Chapter 9. Gene Prediction and Regulation
Chapter 10. Protein Classification and Structure Prediction
Chapter 11. Genome Analysis
Chapter 12. Bioinformatics Programming Using Perl and Perl Modules
Chapter 13. Analysis of Microarrays

Editorial Reviews

This second edition is a qualified success. Every chapter in the second edition appears to be rewritten extensively, and three useful new chapters have been added. As a result, the new edition tops out at 692 pages, and many of the problems with the first edition have been rectified...

Overall, this second edition is a considerable improvement over the first and will be popular on the desks of many scientists as well as many students....If you find that you need a reference that covers the entire breadth of bioinformatics, you need to buy this book.
- DDLClinical Chemistry

The second edition of Bioinformatics: Sequence and Genome Analysis is an excellent textbook for bioinformatics introductory courses for both life sciences and computer science students, and a good reference for current problems in the field and the tools and methods employed in their solution.
- Briefings in Bioinformatics

From the Publisher

Bioinformatics is for the biologist who wants to learn more about the fundamentals of DNA sequence analysis. An analogy for the target audience would be readers who want to know the components of an automobile that make it go, rather than seeking information on how to drive from Tucson to Santa Fe, or on the physics of an internal combustion engine. This audience is probably the largest and, until now, the most neglected….The text [in Bioinformatics] is well formatted and easily read, with many figures and tables. Color is used both effectively and densely. The book is worth purchasing if only for the extensive bibliographies at the end of each chapter. Moreover, the quality and level of explanation in each chapter is generally consistent, something that cannot be said for 'compilation' texts….Bioinformatics is an excellent text for the biologist who wants to learn more about the field, and is well worth exploring by the instructor looking to tackle his or her first bioinformatics course.

Nature Genetics

A textbook based on Mount's (U. of Arizona) undergraduate and graduate courses on applying computational methods to the analysis of DNA and protein sequences. Convinced that people who use a computer program should understand how it works, he explains to biologists the underlying algorithms used and assumptions made, as well as limitations of the methods and strategies. Most of the chapters include a flowchart proposing an orderly use of the methods discussed therein. Tables in hyperlinked form identify web sites where software and programming resources are available. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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