Biological Action of Low Doses of Radiation: A Novel View on the Problem

by L. Kh Eidus

Overview

The stimulation of cell proliferation, the activation of metabolism, the expression of enzymatic genes, and adaptive response are only some of the biological effects that Eidus has found by analyzing experimental data relating to exposure to radiation in the narrow dose range of <.05 to 1.0 Gy. Noting that repeated attempts to explain such effects in terms of traditional radiobiology of high doses, which seeks the mechanisms of the primary damage in DNA, he argues that the target of the damage is in fact plasmatic and intracellular membranes. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Product Details

ISBN-13:	9781590330968
Publisher:	Nova Science Publishers, Incorporated
Publication date:	01/01/2002
Pages:	80
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

	Abstract	vii
	Introduction	ix
Chapter 1	Basic Characteristics of Low-Dose Effects	1
1.1.	Stimulation of Cell Proliferation by Low Dose Irradiation	1
1.2.	Adaptive Response	4
1.2.1.	Adaptive Response to Cell Irradiation	4
1.2.2.	Dependence of Adaptive Response on Radiation Dose-Rate	7
1.2.3.	Adaptive Response of Animal Organisms to Low Doses of Radiation	9
	References	11
Chapter 2	Biophysical Mechanism of Initiation of Low-Dose Effects	17
2.1.	Nature of Target for LDE Initiation	18
2.2.	Role of Nonspecific Reaction of Cells in Initiation of LDE	21
2.2.1.	Nonspecific Regulation of Enzyme Activity by Low-Molecular-Weight Compounds	23
2.2.2.	Compartmentation of Low-Molecular-Weight Compounds in Cell	24
2.3.	Mechanism of LDE Initiation in Terms of NRC Theory	25
	References	26
Chapter 3	Induction of DNA Repair As a Result of Primary Damage of Cell Membranes	29
3.1.	On a Shape of the Dose Curve of Cytogenetic Damages over the Low Dose Range	30
3.2.	On a Nature of Plateau on a Dose Curve of Cytogenetic Damages in the Low-Dose Range and on the Mechanism of Induction of DNA Damages Repair	34
3.3.	On Extrapolation of Dose Dependence of Cytogenetic Damages from High- to Low-Dose Range	38
	References	39
Chapter 4	Interphase Death of Lymphoid Cells is One of Low-Dose Radiation Effects	41
4.1.	Characteristic Features of Thymocyte ID	42
4.2.	Previous Hypotheses about the Mechanisms of initiation of Thymocyte ID	46
4.3	Intercellular Interactions in Initiation of Thymocyte ID	48
4.4.	On the Nature of Mediators in the Intercellular Interaction during Initiation of Thymocyte ID	51
4.5.	Characteristic Features of Thymocyte ID in Terms of the Concept about Its Initiation via Intercellular Interaction of Exposed Cells	53
	References	55
Chapter 5	Remote Effects Induced by Low Doses Ionizing Radiation	59
5.1.	Epidemiological Evidence	60
5.2.	Effect of Low Doses of Ionizing Radiation on Human Health (as judged from the Results of Health Examination of the Accident Recovery Workers (ARWs) of the Chernobyl Nuclear Power Plant (NPP)	63
5.2.1.	Data on the Morbidity Among ARWs	64
5.2.2.	Dose Dependence of Morbidity Among ARWs	66
	References	72
	Conclusion	75
	Index	77