Biological Effects of Fibrous and Particulate Substances

by Takemi Otsuki, Yasuo Yoshioka, Andrij Holian

Overview

This volume examines our current understanding of the biological effects of fibrous and particulate substances, including discussions on nanoparticles. It offers comprehensive information on the latest insights into the immunological effects of various irritants on the human body. Readers will benefit from the contributing authors’ diverse perspectives and extensive discussions of key issues, which include molecular alterations of the immune system and autoimmune diseases in connection with asbestos and silica, among others. The chapters also discuss recommendations, practical methods, and nanosafety science in situations involving exposure to nanotoxic substances.
    Edited in collaboration with the Japanese Society for Hygiene, this book provides up-to-date information on the immunological effects of nanotoxic substances to researchers interested in environmental and occupational health. Presenting a number of recent concepts and findings in the field, it enables readers to gain a comprehensive knowledge of health problems caused by environmental fibrous and particulate substances.

Product Details

ISBN-13:	9784431563099
Publisher:	Springer Japan
Publication date:	08/23/2016
Series:	Current Topics in Environmental Health and Preventive Medicine
Edition description:	Softcover reprint of the original 1st ed. 2016
Pages:	221
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

1. Macrophage and Multinucleated Giant Cell Classification.- 2. NLRP3 Inflammasome-Mediated Toxicity of Fibrous Particles.- 3. Approaching a Unified Theory for Particle-Induced Inflammation.- 4. Reproductive and Developmental Effects of Nanomaterials.- 5. Fibrogenic and Immunotoxic Responses to Carbon Nanotubes.- 6. Potential Hazards of Skin Exposure to Nanoparticles.- 7. Health Effects of Silver Nanoparticles and Silver Ions.- 8. Multiwalled Carbon Nanotube-Induced Pulmonary Fibrogenesis.- 9. Silicates and Autoimmunity.- 10. Asbestos Exposure and Autoimmunity.- 11. T Cell Alteration Caused by Exposure to Asbestos.- 12. Effects of Asbestos Fibers on Human Cytotoxic T Cells.

Editorial Reviews

Reviewer: John T. Pierce, MBBS (MD) PhD(Navy Environmental Health Center)
Description: The first in a series devoted to Current Topics in Environmental Health and Preventive Medicine from the Japanese Society of Hygiene, this book explores both cellular and molecular mechanisms for biological effects of fibrous and particulate substances (including nanomaterials). It furthermore takes a look at immunological effects of silica and asbestos, in the settings of autoimmunity and antitumor immunity.
Purpose: As noted in the unified theory chapter (Bunderson-Schelvan et al.), the emerging field of engineered nanomaterials cries out for a common biological hypothesis unifying their effects with those of more commonly encountered silica and asbestos.
Audience: While scientists in academia, industry, and laboratory toxicology would constitute one cohort of readers, still others will likely arise from fields such as environmental epidemiology and the basic sciences. A review of author affiliations sheds light on likely readers: those in endocrinology, occupational and environmental epidemiology, geriatrics, pediatrics, and preventive medicine.
Features: The 12 chapters span: Macrophage and multinucleated giant cell classification; NLRP3 inflammasome-mediated toxicity of fibrous particles; approaching a unified theory for particle-induced inflammation; reproductive and developmental effects of nanomaterials; fibrogenic and immunotoxic responses to carbon nanotubes; potential hazards of skin exposure to nanoparticles; health effects of silver nanoparticles and silver ions; multiwalled carbon nanotube-induced pulmonary fibrogenesis; unique properties allowing silicates and autoimmunity; asbestos exposure and autoimmunity; T-cell alteration caused by exposure to asbestos; and effects of asbestos fibers on human cytotoxic T-cells.
Assessment: There is likely no more important topic for contemporary occupational medicine discussion than the biological effects of old and new fibrous and particulate substances. One of the challenges for a discussion of engineered nanomaterials is that it represents two profoundly technical topics, engineering of the particles along with systemic and translational biology. Our knowledge of the naturally-derived fibers is neither reassuring nor complete and now we have the broad introduction of engineered nanomaterials. The typical chapter in this book carries 200 supporting references. This is a call for further focused research that would advance knowledge from that of just biological effects to relevant risk assessments and mediation of effects attending the use of these complex materials.

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