Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids / Edition 1

by Ram I. Mahato

Overview

Newcomers to the field of biopharmaceuticals require an understanding of the basic principles and underlying methodology involved in developing protein- and nucleic acid-based therapies for genetic and acquired diseases.

Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids introduces the principles of polymer science and chemistry, as well as the basic biology required for understanding how biomaterials can be used as drug-delivery vehicles. No book to date combines a discussion of high-tech biomaterials-based delivery of protein and nucleic acid drugs with the pharmaceutical or biocompatibility aspects. Featuring contributions from leading experts from around the world, this text discusses physiochemical parameters used for design, development, and evaluation of biotechnological dosage forms for delivery of proteins, peptides, oligonucleotides, and genes. The authors also present biological barriers to extravasation and cellular uptake of proteins and nucleic acids.

Combining an introduction to biomaterial delivery with the latest developments in the field, this is a valuable reference for both the novice student and the practicing scientist on delivery of biomaterials, on biomedical polymers, and on polymer therapeutics. Understanding these core fundamentals is critical to moving on to more advanced study.

Product Details

ISBN-13:	9780849323348
Publisher:	Taylor & Francis
Publication date:	12/28/2004
Edition description:	New Edition
Pages:	708
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

Ram I. Mahato is an assistant professor of pharmaceutics and drug delivery at the Departments of Pharmaceutical Seiences and Biomedical Engineering, University of Tennessee, Memphis.

Table of Contents

Structures, Properties, and Characterization of Biomaterials. Step-Reaction and Ring-Opening Polymerization. Copolymer, Block Copolymers Stimuli-Sensitive Polymers. Polymer Solution Properties, Polymer Networks, Micelles, Dendrimers, Hydrogels. Protein Conjugation, Cross-linking and PEGylation . Complement Activation by Injectable Polymeric Carriers . Biological Membranes and Barriers . Pharmacokinetics of Proteins and Nucleic Acid Drugs . In Vivo Fate of Polymeric Carriers . Subcellular Fate of sProteins and Nucleic Acids. Stability of Proteins and Nucleic Acids . Formulation, Stability and Characterization of Protein and Peptide Drugs. Micro- and Nanoparticulate Polymeric Delivery Systems for Nucleic Acid-based Medicines . Liposomal Delivery Systems of Proteins and Peptides . Mechanisms of Cellular Drug Resistance and Strategies to Overcome It. Transporters as Molecular Targets for Drug Delivery and Disposition. Protein Transduction Domains as a Novel Tool for Delivery of Protein, Peptides and Nucleic Acids. Introduction to Therapeutic Nucleic Acids . Antisense and Antigene Oligonucleotide Delivery . Artificial Nucleic Acid Chaperones . Basic Components of Plasmid-Based Gene Expression Systems . Polymeric Gene Carriers.

Editorial Reviews

Reviewer: J. Howard Rytting, B.A., Ph.D.(University of Kansas Medical Center)
Description: This book is intended essentially as a textbook and/or reference for graduate students and young scientists who are involved in aspects of biotechnology using biomaterials or polymers for the delivery of peptides, proteins, or nucleic acids and related macromolecules. It presents information related to the various approaches used for the design, development, and evaluation of biotechnology-based dosage forms for the delivery of biologically active macromolecules.
Purpose: The editor's stated intention is to provide a textbook for newcomers to the field of delivery of biotechnological products for use in graduate courses in biomaterials and delivery of proteins and nucleic acids. This compilation provides a fairly comprehensive treatment of factors involved in the development of carriers that can be used to deliver macromolecules. It provides an introduction to the use of polymers including synthesis and properties that can be used as adjuvants in the delivery of proteins and other large molecules including their use to modify the properties of the macromolecules as well as the use of carriers such as liposomes for protein and gene therapy.
Audience: The book is primarily written for newcomers to the field of delivery of biotechnology-based medicinal agents. This would include graduate students and other young scientists who have relatively little understanding of the field. It could also serve as a reference for those entering the study and practice of drug delivery of macromolecules as well as more established scientists involved in drug development. Scientists engaged in the development of dosage forms for proteins, peptides, nucleic acids, genes, etc., should find this a useful overview of the area that will assist them in their own developmental work. The chapters are written by experts in their individual disciplines and the book is intended to have sufficient depth and breadth to meet the needs of novice students as well as practicing scientists. The editor has significant expertise in the field and has brought together a number of qualified individuals to write the various chapters.
Features: The editor has organized the chapters to reflect a comprehensive review of the use of polymeric carriers to deliver macromolecules. Topics covered include elements in the use of polymers in general, including structure, properties, synthesis, and many of the characteristics of typical polymers used in drug delivery. Crosslinking and PEGylation of proteins are discussed along with the biocompatibility of polymers. Some of the biological barriers encountered in their use as well as in vivo and subcellular fates of these materials are described. Stability and formulation aspects of proteins and nucleic acids are addressed. The use of micro- and nano-particles as well as liposomal delivery systems is discussed. The utility of transporters and the role of drug resistance and the use of protein transduction domain peptides are presented. Basic elements of nonviral gene therapy, the use of antisense and antigene approaches along with artificial nucleic acid chaperones are all considered. The book provides a good overview of the field with information regarding most of the commonly used approaches to protein and macromolecular drug delivery. The contributors comprise a diverse group of investigators and they develop their own chapters effectively. While there is some overlap in coverage among the various chapters, each stands alone and provides reasonably in-depth coverage of the subject of the chapter. The illustrations, including the limited use of color art, enhance the written discussions well. Overall, the book provides an excellent introduction to the use of biomaterials in the delivery and targeting of proteins, nucleic acids, genes, and other large molecules.
Assessment: The quality of the book is excellent. Although there are the normal differences that occur with a large number of authors contributing chapters, the book is remarkably integrated and rationally organized. It serves a definite need in the discipline as it provides in one source a detailed description of many aspects of drug delivery in a relatively fundamental way. There do not appear to be comparable comprehensive texts of this nature available. This one combines aspects of polymer science and chemistry with basic biology, which should help readers understand how these materials can be used as drug delivery vehicles. Overall, the book could serve as a useful text or reference for appropriate graduate courses as well as for practicing scientists who are interested in developing delivery vehicles for biologically active macromolecules.

Doody's Review Service

"…provides an excellent introduction to the use of biomaterials in the delivery and targeting of proteins, nucleic acids, genes, and other large molecules….excellent…remarkably integrated…rationally organized."
J. Howard Rytting, Ph.D., University of Kansas Medical Center

From the Publisher

3 Stars from Doody