After a ruthless lynch mob kills his mother and tar and feathers him, young Sam Keaton faces the ordeal of being a facially scarred monster, alone and enraged. On a lonely New Mexico mountain top, he is bitten by a mystical werewolf. Sam slowly emerges from his prison of pain and disfigurement, to become a handsome young man, but in his wolf form; the moon doesn't control him, bullets can't kill him, and with a single bite he pulverizes bone. As an adult, Sam kills to possess Katie Jessup for his life partner and wife. When she gives birth to identical twin boys, it begins the creation of the Keaton wolf pack - and their power cannot be controlled.