Bring Back the King: The New Science of De-extinction

by Helen Pilcher

Overview

Helen Pilcher is uniquely qualified to explain the cutting-edge science that makes the resurrection of extinct animals a very real possibility, while acknowledging the serious and humorous aspects of giving a deceased animal a second chance to live. If you could bring back to life a person or animal, what would you choose? Pilcher highlights her own choices from eras gone, including the King of the Dinosaurs, Tyrannosaurus rex, and the King of Rock 'n' Roll, Elvis Presley.

From dinosaurs to dodos and Neanderthals, Bring Back the King reveals how the burgeoning field of DNA science is being used to help resurrect individual animals (did your beloved Fido die before siring offspring?) and entire species from their stony graves. Pilcher describes current initiatives and future plans to restore deceased animals, and uses both science and willful irreverence to assess the ramifications of how these genetic Lazaruses might fare in their brave new world. Along the way, she asks if Elvis could be recreated from the DNA inside a pickled wart, investigates whether it's possible to raise a pet dodo, and considers the odds of a 21st century Neanderthal turning heads on public transport.

Blending the very latest de-extinction technology with cloning, and hard-core popular science with levity, Bring Back the King will generate a lot of thoughtful discussion and a chuckle or two.

Product Details

ISBN-13:	9781472912275
Publisher:	Bloomsbury USA
Publication date:	12/05/2017
Pages:	304
Product dimensions:	5.00(w) x 7.60(h) x 0.90(d)

About the Author

Helen Pilcher is a professional science writer with a Ph.D. in stem-cell biology. A former journalist for Nature online, she also worked as a senior scientist for a biotechnology company, engineering a series of human stem-cell lines for transplantation into damaged human brains. She is also a stand-up comedian who has performed at the Edinburgh Comedy Festival and in clubs across Britain. She lives in Warwickshire, UK.

Table of Contents

Introduction: Bringin' it Back
Extinction may not be forever / The Science of De-extinction / The human genome project / How to choose what to bring back
Chapter 1: The King of the Dinosaurs
The demise of the dinosaurs and their lasting legacy / What could possibly go wrong? / Candidates for resurrection / How to care for your dinosaur / The science of dinosaur de-extinction.
Chapter 2: The King of the Ancient Humans
The discovery of Neanderthals / I want my mummy / Could we clone a Neanderthal? / What's in it for them? / How would a
Neanderthal fare today?
Chapter 3: The King of the Elephants
The giant animals of the late Pleistocene / Meet the mammophant / Pleistocene Park / Sea-cow resurgence
Chapter 4: The King of the Birds
The story of the Dodo / The Great Comeback – the Passenger Pigeon / As undead as a Dodo / Could the Dodo get its own back?
Chapter 5: Australia's King of Beasts … and the Gastric Brooding Frog
Benjamin – last of the Thylacines / Thank heavens for alcohol / Reviving the Thylacine from a pickled pup / Call the Midwife:
Return of the gastric brooding frog.
Chapter 6: The King of Rock 'n' Roll
The Malthusian growth model of Elvis / A brief history of human cloning / The Second Comeback Special / Resurrecting humans /
Legal, ethical and technical issues.
Chapter 7: All Shook Up
We are more than our genes / The role of epigenetics / The torrid tale of the Burcardo
Chapter 8: It's Now or Never
Just because we could, should we? The ethics of de-extinction / Likely candidates / The hurdles / The future of conservation / Has Elvis really left the building?

Editorial Reviews

10/10/2016
Pilcher, a British science journalist and comedian, details how scientists are using the latest advances in molecular genetics and reproductive biology to explore possibilities in the realm of de-extinction. Though de-extinction isn’t an established scientific field—at least not yet—Pilcher reveals that researchers are finding ways to re-create genomes of extinct species and figuring out how to turn such genomes into living, breathing organisms. They’re also attempting to increase the reproductive capacity of endangered species that are not yet extinct. In accessible prose, Pilcher describes many of those techniques as well as the passion of those involved in these efforts. She also explores the current technical limitations and explains why we will likely never be able to bring back extinct species of dinosaurs and the vast majority of species that have been lost. Pilcher presents an insightful discussion of the ethical and ecological reasons why it might not make sense to do so even if we could. Whether she’s dealing with wooly mammoths, peculiar Australian frogs, Neanderthals, or Elvis Presley, she asks provocative questions about both the nature of science and what it means to be human. Pilcher uses humor effectively to keep readers engaged, and there is a great deal here to entertain and educate them. (Jan.)

Publishers Weekly

"[Pilcher] asks provocative questions about both the nature of science and what it means to be human. Pilcher uses humor effectively to keep readers engaged, and there is a great deal here to entertain and educate them." - Publishers Weekly

"A unique perspective on our responsibility to preserve the chain of being of which we are only a part." - Kirkus Reviews

"With humour and accuracy, Helen Pilcher surveys the wondrous array of wildlife de-extinction and preservation projects that employ current breakthroughs in genomic technology. (Plus Elvis, who was a different kind of wild.)" - Stewart Brand author of WHOLE EARTH DISCIPLINE and co-founder of Revive & Restore

"Lighthearted but informative read . . . buy this title as a great insight into modern biology and a more accessible look at de-extinction." - Henrietta Verma, Booklist

"A friendly tour of genetics and cloning, with a bit of history thrown in." - Brian Switek, The Wall Street Journal

"Entertaining and harrowing . . . offer[s] many of popular science's deep and trivial brainy pleasures." - John Williams, The New York Times

From the Publisher

10/15/2016
Can science use genetic engineering to resurrect extinct species, and should it even try? Science writer Pilcher (theknick-knackatory.blogspot.com, formerly Nature) answers with delightfully comprehensible prose. Pilcher traces how scientists recover ancient DNA, map and edit genomes, and clone animals. Though the explanations feel feather-light, the nontechnical language occasionally slips into sloppiness. The author does not call the Cretaceous/Tertiary (Paleogene) Extinction by name and labels 80-million-year-old fossils Jurassic rather than Cretaceous. Digressions about her own pregnancy and Elvis kitsch add little, while the ethical arguments are sometimes inconsistent or incomplete. Pilcher mentions deextinction's possible ecological consequences but advocates disrupting an established ecosystem to transform arctic tundra into grassland. She lauds zoo veterinarian Thomas Hildebrandt for harvesting ova from rhinos yet opposes creating a similar technique for elephants. And she dismisses human cloning with a few authorities' pronouncements, even though the procedure has advocates and is not banned in the United States. This title competes with M.R. O'Connor's Resurrection Science, Ed Regis and George M. Church's Regenesis, and Beth Shapiro's How To Clone a Mammoth. VERDICT Sadly, this extremely nontechnical approach to genetic manipulation's wonders fails to stand out in a crowded field.—Eileen H. Kramer, Georgia Perimeter Coll. Lib., Clarkston

Library Journal

2016-11-01
An intriguing look at the possibilities of bringing the passenger pigeon and other currently extinct species back to life.A British science writer with a doctorate in stem cell biology and a second career as a stand-up comedian, Pilcher examines the possibility of reversing the extinction of our Neanderthal cousins as well as other creatures. "Through interdisciplinary research," she writes, "it's now possible to marry the secrets of ancient DNA with cutting edge genetic technology." This is not an idle fantasy. Although we still have somewhere between 5 and 9 million species on the planet, the author quotes estimates that somewhere between 30 and 150 are becoming extinct every day. As she writes, "over 99 percent of all the species that have ever lived on Earth are no longer with us. They are extinct." Perhaps scientists could resurrect the king of dinosaurs, the Tyrannosaurus rex, from fossils, but the author reminds us that T. rex was not a fussy eater; as such, a human could become a "potential entrée." An even more enticing possibility would be reacquainting ourselves with our cousins, the Neanderthals, "the undisputed King of the Cavemen." Pilcher reports that anthropologists have unraveled "the genetic secrets of the Neanderthal" from fossil remains. A first step in bringing them back to life might be to inject Neanderthal DNA "into a human egg that had…its only nuclear genome removed." Modern genetic evidence shows that they have successfully interbred with humans in the path and thus could do so again. However, in Pilcher's view, their very humanity should preclude engaging in such experimentation. The passenger pigeon is another case in point of why we can't go back in time. Would our farmers tolerate large flocks of hungry passenger pigeons? A more likely candidate for resurrection might be the northern white rhino: there are only three remaining on Earth. A unique perspective on our responsibility to preserve the chain of being of which we are only a part.

Kirkus Reviews