Cell Surface Receptors: A Short Course on Theory and Methods / Edition 3

by Lee E. Limbird

Overview

Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.

Product Details

ISBN-13:	9781441935717
Publisher:	Springer US
Publication date:	10/29/2010
Edition description:	Softcover reprint of hardcover 3rd ed. 2005
Pages:	220
Product dimensions:	6.10(w) x 9.25(h) x 0.36(d)

Table of Contents

to Receptor Theory.- Characterization of Receptors Based on Receptor-Mediated Responses.- Identification of Receptors Using Direct Radioligand Binding Techniques.- Complex Binding Phenomena.- The Preparation and Study of Detergent-Solubilized Receptors.- Quantifying Cell Surface Receptor Binding and Turnover in Intact Cells.