Cell Transplantation for Neurological Disorders: Toward Reconstruction of the Human Central Nervous System / Edition 1

by Thomas B. Freeman, Hakan Widner

Overview

Distinguished medical researchers from around the world review novel neural reconstructive techniques that appear to be beneficial for Parkinson's disease and hold promise for treating Huntington's disease, pain, demyelinating diseases, and stroke. The contributors focus on those diseases for which clinical trials are either ongoing or likely to occur in the near future. Among the topics reviewed are results and rationale for some of the leading transplant programs for the treatment of Parkinson's disease, the use of PET scanning for patient evaluation, autopsy studies of transplant recipients, transplant immunology, fetal tissue transplantation for Huntington's disease, cellular transplantation for the treatment of pain and stroke, and transplantation of myelinating cells. A full discussion of the important ethical issues surrounding the use of fetal tissue for transplantation purposes is also included.

Product Details

ISBN-13:	9781617370434
Publisher:	Springer-Verlag New York, LLC
Publication date:	05/26/2011
Series:	Contemporary Neuroscience
Edition description:	Softcover reprint of hardcover 1st ed. 1998
Pages:	350
Product dimensions:	7.00(w) x 10.00(h) x 0.90(d)

About the Author

Freeman, Thomas B., MD (Univ of South Florida); Widner, Hakan, MD, PhD (Lund Univ)

Table of Contents

1 The Lund Transplant Program for Parkinson’s Disease and Patients with MPTP-Induced Parkinsonism.- 2 Fetal Nigral Transplantation in Parkinson’s Disease: The USF Pilot Program (12- to 24-Month Evaluation).- 3 Toward a Phase III Multicenter Study of Fetal Ventral Mesencephalic Transplants in Patients with Late-Stage Parkinson’s Disease.- 4 PET Studies of Transplantation Therapy.- 5 Neuropathology of Dopaminergic Transplants in Patients with Parkinson’s Disease.- 6 Fetal-Tissue Transplantation for Huntington’s Disease: Preclinical Studies.- 7 Fetal Transplantation for Huntington’s Disease: Clinical Studies.- 8 Topographic Factors Affecting the Functional Viability of Dopamine-Rich Grafts in the Neostriatum.- 9 Immunological Issues in Rodent and Primate Transplants (Allografts).- 10 Transplanting Fetal Neural Xenogeneic Cells in Parkinson’s and Huntington’s Disease Models.- 11 Animal Models of Cerebral Ischemia: Neurodegeneration and Cell Transplantation.- 12 Transplantation Strategies for the Treatment of Pain.- 13 Treatment of Central Nervous System Diseases with Polymer-Encapsulated Xenogeneic Cells.- 14 Transplant Strategies in Myelin Disorders.- 15 Somatic Gene Transfer and Cell Transplantation Strategies for Neurodegenerative Diseases.- 16 Adequately Respecting and Protecting Fetal Tissue Donors and Their Next-of-Kin.

Editorial Reviews

Provides a resource for clinicians working to establish a neural reconstruction program or working in an existing program, emphasizing clinical issues related to neural transplantation. Considers only those diseases which are likely to be amenable to transplant therapy within the next five years, including Parkinson's disease, Huntington's disease, demyelinating diseases, stroke, and pain. Coverage includes strategies using human fetal cells and the use of cross-species cell lines. Of interest to neurosurgeons, immunologists, and molecular and cell biologists. Includes b&w photos. Annotation c. by Book News, Inc., Portland, Or.

Booknews

"The list of contributors reads like a "who's who" in neural transplantation. . .The chapters are generally well-written, logically arranged, and overall the book is a joy to read. . .this is a truly outstanding book, very well written by the leading authorities. It provides a solid basis of knowledge and understanding in this rapidly developing field. . . Not only neuroscientists, but every neurologists, neurosurgeon, and probably many internists may find this book interesting and relevant to the future of their practice. This book should be found in every medical library."-Archives of Neurology

"The editors. . .have gathered an international panel of experts to address the preclinical foundations fro human trials. . .this is an accomplished work."-Neurology

"This book is a statement-of-the-state of the art in neurotransplantation therapy....The book is a good mix of clinical and basic scientific information and was quite enjoyable to read. It establishes that transplantation therapy will have an ever increasing role in the treatment of neurologic conditions. It points out the obstacles ahead and the challenges that must be faced in the future. It should be on every functional neurosurgeon's and neurologist's bookshelf."-Le Journal Canadien des Sciences Neurologiques

"...these chapters are excellent, and give timely perspective and rationale for the development of neurotransplantation....The chapters are well written, logically arranged, and well documented....this excellent book by experts in the field provides great insight for anyone interested in neurological disease. Some of the information in this volume has not been published, and it represents a unique resource. This is an extremely rapidly developing field, and the book will allow readers to quickly understand the importance and breath of the field." -Quarterly Review of Biology

From the Publisher