Cellular Cancer Markers / Edition 1

by Carleton T. Garrett, Stewart Sell

Overview

In Cellular Cancer Markers leading pathologists and physicians review today's most promising cellular cancer markers, an important emerging class of prognostic markers that can be used in the clinical evaluation of cancer patients. The markers reviewed have been chosen because they are biologically relevant to the growth of cells and possess an accurate and reproducible assay for detection. They also are predictors of tumor behavior, are useful in making clinical decisions, and are cost effective.

Cellular Cancer Markers provides a status report for markers of tumor cell activation, proliferation, and longevity that makes possible an informed judgment regarding the value of many newly proposed tumor markers. It also offers insight into the latest approaches to diagnosing cancer and an appreciation of how these marker-based tests can clarify the prognosis of cancer.

Product Details

ISBN-13:	9780896032101
Publisher:	Springer-Verlag New York, LLC
Publication date:	03/03/1995
Series:	Contemporary Biomedicine , #12
Edition description:	1995
Pages:	484
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

About the Author

Garrett, Carleton T., MD, PhD (Medical Coll of Virginia); Sell, Stewart, MD (Univ of Texas)

The contributors represent the specialties of pathology, tumor immunology and biology, anatomic pathology, cellular biochemistry, pharmacology surgery, dermatopathology, histochemistry and electron microscopy, and urology. Most come from U.S. medical centers and the NIH, with some coming from Japan, Italy, and the Netherlands. Institutions prominently represented include Univ of Arizona, Duke Univ Medical Center, NIH, and Univ of Arkansas.

Table of Contents

Ch. 1. Clinical Application of Genetic, Oncogenic, and Differentiation Markers of Cancer.- Ch. 2. ras Proto-Oncogene Activation in Human Malignancy.- Ch. 3. C-myc as a Tumor Marker for Primary Human Cancers.- Ch. 4. p53 in Human Cancer.- Ch. 5. Oncogenes and Tumor-Suppressor Genes in Gynecological Malignancies.- Ch. 6. Genetic Alterations in Colon Cancer.- Ch. 7. Genetic Changes in Breast Cancer.- Ch. 8. Genetic Alterations in Lung Cancer.- Ch. 9. Wilms Tumor-Susceptibility Loci.- Ch. 10. Non-Hodgkin’s Lymphomas.- Ch. 11. Phenotypic Expression of Hodgkin’s Disease: Biologic, Immunologic, and Functional Properties of Reed-Sternberg Cells.- Ch. 12. Melanoma Markers.- Ch. 13. Detection of Minimal Residual Disease (MRD) in Leukemia and Lymphoma.- Ch. 14. P-Glycoproteins in Tumors.- Ch. 15. Genetically Engineered Antitumor Monoclonal Antibodies.- Ch. 16. Targeting Antisense Oligonucleotide Chemotherapy to the Type I Regulatory Subunit of cAMP-Dependent Protein Kinase.- Ch. 17. Summary and Perspective: Assessing Test Effectiveness—The Identification of Good Tumor Markers.

Editorial Reviews

The term tumor markers has traditionally referred to those soluble antigens, hormones, or enzymes that appear in body fluids as a result of an associated clinical cancer. The present volume considers a new class of compounds consisting of cell-associated proteins and nucleic acids, both of which characteristically are not released into serum or other body fluids in any appreciable quantity. Contributions discuss the role(s) of these markers in the mechanism of malignant transformation as well as their effects on clinical outcome, new modes of therapy that molecular approaches are identifying, and issues concerning cost-effective application of the growing number of new tumor markers. Annotation c. Book News, Inc., Portland, OR (booknews.com)

Booknews

The editors should be commended for attempting an extensive compilation of information on cancer markers...-New England Journal of Medicine

From the Publisher