Cellular Drug Delivery: Principles and Practice / Edition 1

by D. Robert Lu, Svein Øie

Overview

An authoritative and up-to-date survey of the fundamental principles, and practice of drug delivery at the cellular level. On the principles side, the authors discuss the broad spectrum of cellular delivery, ranging from coverage of cell-mediated immunity, gene delivery, and protein targeting, to cellular drug transport, cellular drug permeability, and a variety of carrier system related to targeted drug delivery. On the practice side, the authors focus on technological developments in cellular drug delivery, including novel formulations for the delivery of DNA and antisense oligonucleotides ,as well as drug targeting with immunoglobulin formulations and antibody-mediated approaches.

Product Details

ISBN-13:	9781617374555
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/05/2010
Edition description:	Softcover reprint of hardcover 1st ed. 2004
Pages:	376
Product dimensions:	7.00(w) x 9.90(h) x 0.90(d)

Table of Contents

to Cellular Drug Delivery: Present Realities and Future Prospects.- I. Fundamentals of Cell Biology and Cellular Drug Delivery.- 1. Cellular Structure, Function, and Membrane Transport.- 2. Cellular Growth, Development, and Defensive Response.- II. Principles of Cellular Drug Delivery.- 3. Augmentation of Cell-Mediated Immunity to Virus.- 4. Development of Nonviral DNA Delivery Systems.- 5. Nucleic Acid Cellular Delivery.- 6. TAT and TAT-Like Peptides for Protein Transduction and Intracellular Drug Delivery.- 7. Carrier-Mediated Mechanisms for Cellular Drug Transport.- 8. ABC Transporter Proteins and Cellular Drug Resistance: P-Glycoprotein and Analogous Transporters.- 9 Human Intestinal Cellular Characteristics and Drug Permeability.- 10. Targeted Drug Delivery to Tumor Cells Using Colloidal Carriers.- 11. Biological Protein Nanostructures and Targeted Drug Delivery.- III. Practice and Technology of Cellular Drug Delivery.- 12. Formulation Considerations for DNA-Based Therapeutics.- 13. Cationic Microparticles and Emulsions As Effective Delivery Systems for Immune Stimulatory CpG DNA.- 14. Transdermal Delivery of Antisense Oligonucleotides.- 15. Fc Receptor Targeting With Recombinant Immunoglobulins and Immunoglobulin Formulations.- 16. Antibody-Mediated Drug Delivery in Cancer Therapy.- 17. Automated Property Profiling for Cellular Drug Delivery.

Editorial Reviews

3 Stars from Doody

Reviewer: Steven Mark Lonesky, RPh (Teva Pharmaceuticals USA)
Description: This book begins with a great review of cellular biology and continues with a step-by- step comprehensive look at targeted therapy. It also gives the reader a glimpse into the future of this very important field.
Purpose: The purpose is to serve as a reference on intracellular drug delivery. The authors have accomplished their objective.
Audience: The editors don't state a target audience, but I believe the book is meant for students. It also functions as a thorough review for ex-students like myself who have an underlying interest in the future of drug therapy.
Features: The book takes a comprehensive look at drug therapies that go directly to the source of many diseases that afflict the human race. The chapter on antibody cancer therapy is thorough and well written. The diagrams and illustrations are simple, uncluttered, easy to follow and complement the text.
Assessment: This is a good overview of site specific therapy. It would make a good textbook for undergraduate students in any of the science or medical fields. I will use it as a reference to revisit periodically when I have a specific question regarding cell biology.

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