Chemistry and Pharmacology / Edition 1

Chemistry and Pharmacology / Edition 1

by Geoffrey A. Cordell
ISBN-10:
0124695493
ISBN-13:
9780124695498
Pub. Date:
06/16/1997
Publisher:
Elsevier Science
ISBN-10:
0124695493
ISBN-13:
9780124695498
Pub. Date:
06/16/1997
Publisher:
Elsevier Science
Chemistry and Pharmacology / Edition 1

Chemistry and Pharmacology / Edition 1

by Geoffrey A. Cordell
$260.0
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Overview

Internationally acclaimed for more than 40 years, The Alkaloids,/B>, founded by the late Professor R. H. F. Manske, continues to provide outstanding coverage of the rapidly expanding field of the chemotaxonomy, structure elucidation, synthesis, biosynthesis, and biology of all classes of alkaloids from higher and lower plants, marine organisms, or various terrestrial animals. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids.

Over the years, this series has become the standard in natural product chemistry to which all other book series aspire. The Alkaloids: Chemistry and Biology endures as an essential reference for all natural product chemists and biologists who have an interest in alkaloids, their diversity, and their unique biological profile.


Product Details

ISBN-13: 9780124695498
Publisher: Elsevier Science
Publication date: 06/16/1997
Series: The Alkaloids , #49
Pages: 405
Product dimensions: 6.00(w) x 9.00(h) x (d)

About the Author

Professor Emeritus Geoffrey A. Cordell obtained his Ph.D. in synthetic natural product chemistry at the University of Manchester in 1970. After two years as a NATO postdoctoral fellow at the Department of Chemistry, M.I.T., he joined the College of Pharmacy, University of Illinois at Chicago (UIC). A Professor since 1980, he served as a Department Head for 12 years and as Interim Dean of the College of Pharmacy for almost three years, as well as holding several other senior academic and research administrative positions at the Department, College, and Campus levels. He was the Co-founder of the US - Thai Consortium for Pharmacy Education, which developed and trained faculty for six new schools of pharmacy in Thailand. He retired from the University of Illinois in 2007. Since 1983, he has served as President of Natural Products Inc., a consulting company.

He is the author of about 600 research publications, book chapters, comprehensive reviews and professional publications; is the author of two books, with three more in progress; the editor of 37 books, including 29 volumes in the series “The Alkaloids: Chemistry and Biology”; is Associate Editor-in-Chief of the Chinese Journal of Natural Medicines; and a member of the Editorial Advisory Board of 26 international scientific journals. He is a former President of the American Society of Pharmacognosy, and is also an Honorary Member.

In 1981, he was an Alexander von Humboldt Fellow at the University of Munich with Professor Hildebert Wagner. He is an elected Fellow of the Royal Chemical Society, the Linnean Society of London, the American Society of Pharmacognosy, and the American Association of Pharmaceutical Scientists. In addition to assisting international organizations and corporations in several countries around the world to develop their research and academic programs, he is an Honorary Professor at Sichuan University, Chengdu, China; and at Amity University, Noida, India. He is also a Visiting Professor at universities in Peru, Malaysia, and Brasil, and an International Collaborative Partner of the UTAR Global Research Network in Malaysia in the areas of biodiversity and cancer. In addition, he is a member of the International Advisory Board of several natural product research institutes. His interests include the chemistry and biosynthesis of alkaloids, the sustainability and quality control of medicinal agents, the remote detection of biologically active natural products, and the use of vegetables as chemical reagents.

Table of Contents

Contributorsvii
Prefaceix
C[subscript 20]-Diterpenoid Alkaloids
I.Introduction2
II.Classification, Distribution and Occurrence3
III.Biosynthesis and Biogenesis85
IV.Spectroscopy94
V.Stereochemistry and Reactions231
VI.Pharmacology247
VII.Addendum261
Acknowledgements264
References264
The Iboga Alkaloids and their Role as Precursors of Anti-neoplastic Bisindole Catharanthus Alkaloids
Introduction281
II.Isolation of New Alkaloids284
III.Structural and Physical Characteristics287
IV.Biosynthesis293
V.Synthetic of Iboga Alkaloids296
VI.Chemical Reactivity of Iboga Alkaloids321
VII.Oxidative Coupling of Catharanthine and Vindoline333
VIII.Oxidative Coupling of Catharanthine and Vindoline Analogues340
IX.Other Synthetic Routes to Bisindole Catharanthus Alkaloids344
X.Overview of the Stereoselectivity of the Coupling Processes357
XI.Alkaloid Production in Cell Cultures359
XII.Semi-Synthetic Bisindole Compounds with Anti-neoplastic Activity362
XIII.Other Biological Activity of Iboga Alkaloids365
Acknowledgements366
References366
Cumulative Index of Titles377
Index387
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