Chemistry of Antibiotics and Related Drugs

by Mrinal K. Bhattacharjee

Overview

This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels.

Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.

Product Details

ISBN-13:	9783031075827
Publisher:	Springer-Verlag New York, LLC
Publication date:	08/23/2022
Sold by:	Barnes & Noble
Format:	eBook
File size:	16 MB
Note:	This product may take a few minutes to download.

About the Author

Mrinal Bhattacharjee did his Ph.D. from The Ohio State University and currently works as an Associate Professor at Long Island University where he teaches Biochemistry, Organic Chemistry and General Chemistry classes. His research interests include molecular biology of oral bacteria and the discovery and study of new antibiotics, especially from natural sources.

Table of Contents

Chapter 1: Introduction.- Chapter 2: Development of resistance to antibiotics.- Chapter 3: Antibiotics that inhibit cell wall synthesis.- Chapter 4: Antimetabolites: Antibiotics that inhibit nucleotide synthesis.- Chapter 5: Antibiotics that inhibit nucleic acid synthesis.- Chapter 6: Antibiotics that inhibit protein synthesis.- Chapter 7: Antibiotics that affect the membrane and other structural targets.- Chapter 8: Antifungals, Antimalarials and Antivirals.- Chapter 9: Alternative Approaches for Antibiotic Discovery.- Chapter 10: Global Action Plan and Antibiotic Stewardship.

Editorial Reviews

Reviewer: Benjamin E Blass, Ph.D.(Temple University School of Pharmacy)
Description: This book provides excellent coverage on a wide range of antimicrobials and antibiotics as well as their chemistry base. The collection is presented in a set, based on the mechanisms of action. The book also provides excellent overviews on the development of drug resistance, antibiotic stewardship, and new approaches to the identification of novel antimicrobials and antibiotics. The first edition was published in 2016.
Purpose: The overall goal of the book is to provide readers with an understanding of how antimicrobial agents and antibiotics eliminate pathogens, how resistance mechanisms can lead to the development of resistant organisms, and antibiotic stewardship (last chapter). All of these objectives are worthwhile and met by the book.
Audience: This book is too advanced for undergraduate students, but would be appropriate for graduate students interested in the identification of novel antibiotics. It might also be useful for scientists who are new to the field of antimicrobial agents and antibiotics. The author's credentials indicate he is a well-established scientist with a high level of credibility.
Features: The book provides a thorough explanation of the chemistry of a wide range of antimicrobial agents and antibiotics. The illustrations are well presented and the chapter on antibacterial stewardship is particularly well written. In addition, the organizational layout of the book (establishing sets of compounds based on mechanisms of action) is a useful approach. If a third edition is written, I would recommend adding an appendix that contains a table of the compounds described in the text that indicates if the compounds have been approved for clinical use, as well as their generic and trade names.
Assessment: The overall quality of the book is high. In comparison to books that cover similar material, such as Foye's Principles of Medicinal Chemistry, 8th Edition, Roche et al. (Wolters Kluwer, 2020), this book fares well.

Doody's Review Service

In the Chemistry of Antibiotics and Related Drugs, Bhattacharjee (chemistry and biochemistry, Long Island Univ.) writes about the many different classes of compounds approved over the last century that still are, or have been, used to treat infectious diseases. The book is organized around the targets of these compounds. … this book is heavily referenced and will be valuable to practicing researchers and advanced students. Summing Up: Recommended. Upper-division undergraduates and above; faculty and professionals.” (P. W. Baures, Choice, Vol. 54 (9), May, 2017)

From the Publisher