Chiral Separations

by Satinder Ahuja

Overview

Chronicles the theory and practical applications of chiral technology by focusing on the efficient preparation, isolation, and separation of chiral molecules in optically pure forms. Discusses asymmetric synthesis and chiral resolution in a variety of contexts, including enantioselective reactions and additions, enzyme-catalyzed reactions, chromatographic methods with various chiral stationary phases or chiral discriminators, and enantioselective membrane transport.

Product Details

ISBN-13:	9780841234079
Publisher:	American Chemical Society
Publication date:	05/05/1996
Series:	Acs Professional Reference Books
Pages:	368
Product dimensions:	6.14(w) x 9.21(h) x 0.88(d)

Table of Contents

Chiral Separations and Technology: An Overview, S. Ahuja

Editorial Reviews

"[T]he editor has attempted to assemble chapters that treat a wide variety of topics that relate to dissymmetric molecules. . . . The two chapters dealing with the development of methods for enantiomer and diastereomer separation are particularly strong, and highly useful to those in the analysis community. . . . This volume is not a handbook categorizing all of the methods to develop large-scale preparative methods for the separation of enantiomers or diastereomers, and neither is it a comprehensive presentation of all known analytical methodologies to quantitate the degree of such separations. What is present is a [sic] overview of each area, which provides a decent introduction to these fields. Fortunately, each chapter is liberally annotated with literature references that lead readers as deep as they need to go into each topic. The book is ... quite useful to those seeking to separate and analyze dissymmetric chemical entities."—Journal of Pharmaceutical and Biomedical Analysis

"This volume is one of the few contributions in a book format to the very exciting field of chiral separation and technology. This process represents an outstanding tool for separating molecules in many fields, such as: drug synthesis, drug pesticide and other molecules containing asymmetric carbon (enantiomers) for various applications. Nowadays, besides chiral separation, the so-called chiral technology, which deals with technological issues of chirality, also emerged. This technology is based on the synthesis of new molecules using other means beside those of the classical organic synthesis. . . . This book is co-authored by fifteen contributors. They are scientists and practitioners with deep knowledge in this new field of research. This volume is highly recommended to all scientists interested in separation techniques or in advanced organic synthesis and also to specialists from pharmaceutical industries."—Cellulose Chemistry and Technology

From the Publisher

For chemists in pharmaceuticals, agriculture, biology, and synthetic organic chemistry, explains the methods for separating molecules that are identical except for being non-superimposable mirror images of each other. Details the general strategy, available chiral stationary phases and criteria for selecting among them, choosing chromatographic methods, and improving the separations. Suggests that liquid-membrane systems for the enantioselective transport of chiral molecules may turn out to be the best in terms of cost and convenience. Annotation c. by Book News, Inc., Portland, Or.

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