Chronic Liver Failure: Mechanisms and Management / Edition 1

by Pere Ginès, Patrick S Kamath, Vicente Arroyo

Overview

Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems. Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.

Product Details

ISBN-13:	9781607618652
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/03/2010
Series:	Clinical Gastroenterology
Edition description:	2011
Pages:	590
Product dimensions:	6.30(w) x 9.10(h) x 1.50(d)

Table of Contents

Preface v

Acknowledgements ix

Contributors xv

Part I The Organ

Cells in the Liver-Functions in Health and Disease Fabio Marra Maurizio Parola 3

Liver Physiology Alexander Sendensky Jean-François Dufour 33

Assessment of Liver Function in Clinical Practice Hamed Khalili Barham Abu Dayyeh Lawrence S. Friedman 47

Physiology of the Splanchnic and Hepatic Circulations Gautam Mehta Juan-Carlos García-Pagán Jaime Bosch 77

Fibrosis as a Major Mechanism of Chronic Liver Disease Lars P. Bechmann Scott L. Friedman 91

Stem Cells and Chronic Liver Failure: Potential New Therapeutics Aiwu Ruth He Arun Thenappan Feras J. Abdul Khalek Lopa Mishra 109

The Role of Inflammatory Mediators in Liver Failure Joan Clària Marta López-Parra Esther Titos Ana González-Périz 131

Genomics of the Liver in Health and Disease Konstantinos N. Lazaridis 155

Part II Effects of Liver Failure on Organ Systems

Hepatic Encephalopathy and Alterations of Cerebral Function Juan Córdoba Rita García-Martinez 171

Bacterial Translocation and Alterations of the Digestive System Reiner Wiest 189

SIRS, Bacterial Infections, and Alterations of the Immune System J. Macnaughtan V. Stadlbauer R.P. Mookerjee R. Jalan 219

Regulation of the Extracellular Fluid Volume and Renal Function Jens H. Henriksen 239

The Heart in Chronic Liver Failure Hongqun Liu Soon Woo Nam Samuel S. Lee 269

Haemostasis Abnormalities in Chronic Liver Failure Armando Tripodi 289

The Systemic and Splanchnic Circulations Yasuko Iwakiri 305

Hepatic Microcirculation Chittaranjan Routray Vijay Shah 323

Angiogenesis and Vascular Growth in Liver Diseases Manuel Morales-Ruiz Sònia Tugues Wladimiro Jiménez 343

Pulmonary Alterations in Chronic Liver Failure Michael J. Krowka Aynur Okcay 361

Adrenal Function in Chronic Liver Failure Javier Fernández Juan Acevedo 377

Part III Management of Chronic Liver Failure

Antibiotic Prophylaxis and Management of Bacterial Infections Joseph K. Lim Puneeta Tandon Guadalupe Garcia-Tsao 395

Management of Ascites and Hyponatremia Andrés Cárdenas Pere Ginès 411

Management of Renal Failure Vicente Arroyo Mónica Guevara 429

Correction of Abnormalities of Haemostasis in Chronic Liver Disease Marco Senzolo Andrew Kenneth Burroughs 453

The Treatment and Prevention of Variceal Bleeding Juan G. Abraldes Jaime Bosch Juan Carlos García-Pagan 477

Extracorporeal Artificial Liver Support Systems Rafael Bañares María-Vega Catalina 501

Issues in Transplantation of Patients with Chronic Liver Failure Michael D. Leise W. Ray Kim Patrick S. Kamath 521

Chronic Liver Disease in the Intensive Care Andrew Slack Julia Wendon 541

Subject Index 561

Editorial Reviews

Reviewer: Paul Angulo, Professor of Medicine(University of Kentucky College of Medicine)
Description: This is an outstanding review of basic and clinical aspects of chronic liver failure.
Purpose: The purpose is to provide a comprehensive overview of this condition.
Audience: The book is intended for a wide range of healthcare personal including students, residents, fellows, and established practitioners.
Features: It covers a wide range of topics related to chronic liver failure. The in-depth review of clinically relevant topics is its best feature. The color figures in and of themselves help in understanding concepts presented in the chapters.
Assessment: This outstanding book on chronic liver failure is one that every practicing gastroenterologist and hepatologist should have in the office to consult on a daily basis.

Doody's Review Service

From the reviews:

“This is an outstanding review of basic and clinical aspects of chronic liver failure. … The book is intended for a wide range of healthcare personal including students, residents, fellows, and established practitioners. … This outstanding book on chronic liver failure is one that every practicing gastroenterologist and hepatologist should have in the office to consult on a daily basis.” (Paul Angulo, Doody’s Review Service, April, 2011)

From the Publisher