Cigarette Smoke and Oxidative Stress

by Barry B. Halliwell (Editor), Henrik E. Poulsen (Editor)

Overview

The mechanism by which cigarette smoke causes or contributes to inflammatory diseases like chronic obstructive pulmonary disease, cardiovascular disease and cancer remains unclear. Recent developments in our knowledge of cellular signaling suggest that cigarette smoke may cause oxidative stress in cellular systems. The assessment, consequences and possible modulation of these effects are discussed in this book which will interest oncologists and researchers in Biochemistry.

Product Details

ISBN-13:	9783540314103
Publisher:	Springer Berlin Heidelberg
Publication date:	07/26/2006
Edition description:	2006
Pages:	407
Product dimensions:	6.10(w) x 9.25(h) x 0.04(d)

Table of Contents

Oxidative Stress.- Tobacco Smoke Constituents Affecting Oxidative Stress.- Oxidative Modifications of Proteins and Lipids by Cigarette Smoke (CS). A Central Role for Unsaturated Aldehydes in CS-Mediated Airway Inflammation.- Cigarette Smoke-Induced Redox Signaling and Gene Expression in In Vitro and In Vivo Models.- Redox Effects of Cigarette Smoke in Lung Inflammation.- Oxidative Stress in the Pathogenesis of Chronic Obstructive Pulmonary Disease.- Modulation of Cigarette Smoke Effects by Diet and Antioxidants.- Modulation of Cigarette Smoke Effects by Antioxidants: Oxidative Stress and Degenerative Diseases.- Smoking Depletes Vitamin C: Should Smokers Be Recommended to Take Supplements?.- Experimental In Vitro Exposure Methods for Studying the Effects of Inhalable Compounds.- Oxidative Stress in Laboratory Animals Exposed to Cigarette Smoke, with Special Reference to Chronic Obstructive Pulmonary Disease.- Pulmonary Effects of Cigarette Smoke in Humans.- Smoking and Oxidative Stress: Vascular Damage.- Nrf2: a Transcription Factor that Modifies Susceptibility to Cigarette Smoke-Induced Pulmonary Oxidative Stress and Emphysema.- Tobacco Smoke and Skin Aging.- Cigarette Smoke and Oxidative DNA Modification.

Editorial Reviews

Reviewer: Joel C Seidman, MD (William Beaumont Hospitals)
Description: This is a unique book that attempts to summarize the current knowledge about the constituents of cigarette smoke (rather than tars), their biochemistry and interaction with human tissues, particularly with their capacity in some instances to foster oxidative stress (which is carefully defined), potentially leading to bronchopulmonary structural anomalies and pathophysiology already known for their association with cigarette smoking. In aggregate, the work aims especially to explain or speculate about the molecular biologic mechanisms underlying chronic obstructive pulmonary disease, elaborate upon methods of resisting oxidative stress as possible means of mitigation, and establish the basis, perhaps predominantly genetic, for the observed variability in human adverse responses to cigarette smoke. The editors derive insight and authored input from an international panel of contributors of eclectic knowledge and experience.
Purpose: In aggregate, a comprehensive attempt is made to adopt observations of authorities from diverse experience to provide, from basic laboratory research, models of oxidative stress induced by cigarette smoke and how such events actually induce or might foster structural and functional consequences upon otherwise normal bronchopulmonary health. The aim is not to establish that cigarette smoking is a health hazard and that abstinence is a prime goal in prevention and treatment, long-accepted truisms. Rather, the intent is to speculate upon what role antioxidants might have in reducing the consequences and identify those individuals who might be an exceptional risk when oxidative stress is imposed. Thus, future scientific investigation might be aptly aimed at additional means to mitigate smoking-induced bronchopulmonary injury.
Audience: The audience would be very limited: basic scientists with in-depth background oxidative-reductive biochemistry. Few practitioners would find the book useful to practice.
Features: It focuses primarily upon characterization of known outcomes and speculation regarding potential consequences of oxidative stress induced by cigarette smoke upon bronchopulmonary biology.
Assessment: The book achieves its likely intended goals well for those experts whose knowledge and experience is in this area. To a practitioner, it comes across as somewhat unreachable, and is a reference that would be an unlikely resource.

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