Clinical Benefits of Leukodepleted Blood Products / Edition 1

by Joseph Sweeney

Overview

Joseph Sweeney, Andrew Heaton he presence of allogeneic leukocytes in blood products received little T attention until the mid-1950s when these "passenger" cells were im­ plicated in the etiology of febrile transfusion reactions, and early strate­ gies based on centrifugation were developed to effect their removal. In recent decades and, particularly in the past five years, there has been an accumulation of literature implicating leukocytes in a wide variety of undesirable reactions to blood transfusion. White cells are the least numerous of the cellular elements in blood and ratios of white cells to platelets and white cells to red cells are ap­ proximately 1:15 to 1:1000 respectively. This ratio is maintained in whole blood, but may be altered slightly in the process of component preparation. Any production or processing step which intentionally decreases this ratio will result in a product which can be described as white cell depleted. It has, however, become more common to define the outcome as a residual white cell content, rather than a decrease in cellular ratios, although the latter makes more sense on theoretical grounds, since deple­ tion of white cells needs to be put in the context of any unintentional loss of red cells or platelets. The end result of this intentional processing step, therefore, is generally expressed as the residual absolute number of white cells or as the degree of difference in white cell content, the latter expressed as either a percentage change or as a logarithmic reduction.

Product Details

ISBN-13:	9781570591228
Publisher:	Springer Berlin Heidelberg
Publication date:	01/01/1995
Series:	Medical Intelligence Unit
Edition description:	Softcover reprint of the original 1st ed. 1995
Pages:	198
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Sweeney, Joseph, MD (Miriam and Roger William Hospitals); Heaton, Andrew, MD (Irwin Memorial Blood Center)

The contributors represent the specialties of blood banking, pathology, surgery, cardiac surgery, and transfusion medicine. Most are from academic and clinical centers in the U.S. and abroad. Institutions prominently represented include George Washington Univ, Irwin Memorial Blood Center in San Francisco, Univ of Virginia, Hammersmith Hospital, and Rode Kruis Bloedbank Amsterdam.

Table of Contents

1. Introduction.- 2. Methods of Leukodepletion.- 3. Enumeration of Low White Cells.- 4. Mechanisms of Leukodepletion by Filtration.- 5. Role of Contaminating White Blood Cells in the Storage Lesions of Red Cells and Platelets.- 6. Leukodepletion to Prevent Transfusion Reactions: Effects on Cytokines and Other Biologic Response Modifiers.- 7. Leukodepletion and Alloimmunization.- 8. Role of Donor Leukocytes and Leukodepletion in Transfusion-Associated Viral Infections.- 9. Leukocyte Depletion and Transfusion-Induced Immunomodulation.- 10. The Role of Leukocyte Depletion in Prevention of Transfusion-Related Acute Lung Injury.- 11. The Role of Leukocyte Depletion in the Prevention of Reperfusion Injury Associated with Open Heart Surgery.- 12. The Use of Leukodepleted Blood Components for Neonates and Infants.- 13. Leukocyte Depleted Blood Transfusion in Hematopoietic Stem Cell Reconstitution Therapy.- 14. Cost-Effectiveness of Leukodepletion.

Editorial Reviews

Reviewer: Simone Silberman, MD (Loyola University Medical Center)
Description: This is the first edition for this state-of-the-art textbook on an exciting new development in transfusion medicine practice. It brings together information that is presently scattered throughout the medical literature.
Purpose: The purpose is to provide up-to-date information on leukodepleted blood products from their preparation to their clinical usage. The book has accomplished its aim in a masterful manner.
Audience: The book is a valuable resource for all those concerned with this field, from practicing oncologists, pediatricians, and surgeons to immunohematologists who wish to keep up with the latest developments in this area.
Features: The book contains 14 chapters that are broken down into specific themes from methodology to the impact of leukodepletion on cellular blood elements to the clinical advantages and usage of leukodepleted components. Each chapter is preceded by a short summary and ends with a list of concluding statements. The text is well written and enhanced by summary charts, figures, and simple black-and-white diagrams. The chapters are well referenced up through 1994. As with multiauthored texts, there are some unavoidable repetitions.
Assessment: The book is timely and contains a vast amount of up-to-date information. It is well worth purchasing and provides a useful addition to the medical literature base.

Doody's Review Service

3 Stars from Doody

This is the first edition for this state-of-the-art textbook on an exciting new development in transfusion medicine practice. It brings together information that is presently scattered throughout the medical literature. The purpose is to provide up-to-date information on leukodepleted blood products from their preparation to their clinical usage. The book has accomplished its aim in a masterful manner. The book is a valuable resource for all those concerned with this field, from practicing oncologists, pediatricians, and surgeons to immunohematologists who wish to keep up with the latest developments in this area. The book contains 14 chapters that are broken down into specific themes from methodology to the impact of leukodepletion on cellular blood elements to the clinical advantages and usage of leukodepleted components. Each chapter is preceded by a short summary and ends with a list of concluding statements. The text is well written and enhanced by summary charts, figures, and simple black-and-white diagrams. The chapters are well referenced up through 1994. As with multiauthored texts, there are some unavoidable repetitions. The book is timely and contains a vast amount of up-to-date information. It is well worth purchasing and provides a useful addition to the medical literature base.

Simone Silberman

Describes the status of leukodepleted blood products, structured such that each chapter can be read as a single unit. Covers methods of leukodepletion, enumeration of white blood cells, the role of contaminating white blood cells, leukodepletion to prevent transfusion reactions, the use of blood components for neonates and infants, and cost-effectiveness of leukodepletion. Includes chapter summaries and conclusions, and b&w diagrams and tables. Of interest to surgeons, internists, hematologists, oncologists, and transfusion specialists. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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