Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics

by William Clarke PhD, MBA, Amitava Dasgupta Ph.D, DABCC

Overview

Clinical Challenges in Therapeutic Drug Monitoring: Special Populations, Physiological Conditions and Pharmacogenomics focuses on critical issues in therapeutic drug monitoring including special requirements of therapeutic drug monitoring important to special populations (infants and children, pregnant women, elderly patients, and obese patients). The book also covers issues of free drug monitoring and common interferences in using immunoassays for therapeutic drug monitoring.

This book is essential reading for any clinician, fellow, or trainee who wants to gain greater insight into the process of therapeutic drug monitoring for individual dosage adjustment and avoiding drug toxicity for certain drugs within a narrow therapeutic window. The book is written specifically for busy clinicians, fellows, and trainees who order therapeutic drug monitoring and need to get more familiar with testing methodologies, issues of interferences, and interpretation of results in certain patient populations.

Product Details

ISBN-13:	9780128020258
Publisher:	Elsevier Science
Publication date:	05/17/2016
Pages:	376
Product dimensions:	7.50(w) x 9.25(h) x (d)

About the Author

William Clarke received his PhD in Analytical Chemistry from the University of Nebraska in Lincoln in 2000, followed by a post-doctoral fellowship in Clinical Chemistry at the Johns Hopkins School of Medicine, ending in 2002. In addition, he received an MBA focused on Medical Services Management from the Carey School of Business at Johns Hopkins in 2007. He is an Associate Professor in the Department of Pathology, as well as the director of both Point-of-Care Testing and Clinical Toxicology for The Johns Hopkins Hospital. Dr. Clarke is board certified in Clinical Chemistry by the American Board of Clinical Chemistry, and is a Fellow of the National Academy of Clinical Biochemistry. Dr. Clarke has published, as author or co-author, over 100 peer-reviewed manuscripts and book chapters. He is the Editor of the book Contemporary Practice in Clinical Chemistry, and the Co-Editor-in-Chief for the journal Practical Laboratory Medicine.

Amitava Dasgupta received his Ph. D in chemistry from Stanford University and completed his fellowship training in Clinical Chemistry from the Department of Laboratory Medicine at the University of Washington School of Medicine at Seattle. He is board certified in both Toxicology and Clinical Chemistry by the American Board of Clinical Chemistry. Currently, he is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Kansas Medical Center and Director of Clinical Laboratories at the University of Kansas Hospital. Prior to this appointment he was a tenured Professor of Pathology and Laboratory Medicine at the University of Texas McGovern medical School from February 1998 to April 2022. He has 252 papers to his credit. He is in the editorial board of four journals including Therapeutic Drug Monitoring, Clinica Chimica Acta, Archives of Pathology and Laboratory Medicine, and Journal of Clinical Laboratory Analysis.

Table of Contents

Overview of Therapeutic Drug Monitoring

Immunoassays and Issues with Interference in Therapeutic Drug Monitoring

Application of Chromatography Combined with Mass Spectrometry in Therapeutic Drug Monitoring

Clinical Utility of Free Drug Monitoring

Therapeutic Drug Monitoring of Newer Antiepileptic Drugs

Therapeutic Drug Monitoring of Antiretrovirals

Therapeutic Drug Monitoring in Infants and Children

Therapeutic Drug Monitoring in Pregnancy

Therapeutic Drug Monitoring in the Elderly

Therapeutic Drug Monitoring in Obese Patients

Special Issues in Therapeutic Drug Monitoring in Patients with Uremia, Liver Disease, and Critically Ill Patients

Integrating Therapuetic Drug Monitoring and Pharmacogenomics

Warfarin Pharmacogenomics

Drug Monitoring in Alternative Matrices

Integrating and Supporting Therapeutic Drug Monitoring in a Hospital System

What People are Saying About This

From the Publisher

This concise and highly accessible guide surveys critical issues in therapeutic drug monitoring for non-toxicologists who want to gain greater insight into the unique requirements of special populations and learn how to avoid drug toxicity within a narrow therapeutic window

Editorial Reviews

Reviewer: Valerie L Ng, PhD MD(Alameda County Medical Center/Highland Hospital)
Description: This book is a compilation of "critical issues in therapeutic drug monitoring."
Purpose: The purpose is to provide a single, up-to-date reference for critical issues in therapeutic drug monitoring. These worthy objectives are somewhat met by the authors.
Audience: This is intended for clinicians, toxicologists, medical students, and nurses. This is a broad audience and it is correctly identified — many will find this book interesting.
Features: This seemingly small book is true to its title, covering a wealth of "clinical challenges in therapeutic drug monitoring" (TDM). It is logically laid out, beginning with methodology descriptions (four chapters) and devoting the remaining 10 chapters to special clinical situations and related TDM considerations. I must admit I found the material uneven. Certain chapters are absolutely superb (e.g., TDM and pharmacists' role). Others are somewhat lacking, one of which is the chapter on pharmacogenomics and warfarin. The first sentence in the section (12.4) is seemingly contradictory. It contains a brief discussion of the direct oral anticoagulants (DOACs), but refers to them instead by an outmoded term (i.e., NOACs). The chapter on TDM in obese patients does not discuss the still controversial issue of how to dose low molecular weight heparin (LMWH) in these patients. Furthermore, LMWH dosing is only discussed in relationship to pregnancy, not as prophylaxis for deep venous thrombosis (DVT), a more commonly used indication and commonly undertaken in the elderly and/or obese (the specialized populations discussed in this book).
Assessment: Be forewarned — this book hits the highlights of TDM but it is not comprehensive. It is useful if you want a concise review of hot topics in TDM.

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