CURED I - LENT Late Effects of Cancer Treatment on Normal Tissues / Edition 1

by Philip Rubin, L.S. Constine, Lawrence B. Marks, Paul Okunieff

Overview

The rapid advances in radiation oncology, radiation biology, and radiation therapy physics have led to an accumulation of information on the interactions of radiation with other therapeutic modalities, such as the wide array of chemotherapeutic agents being employed in combination with radiation therapy, as well as the multiple biologic response modi? ers that are being used in combination with radiation therapy. It is now recognized that they have a signifi cant impact on normal tissue toxicities. The radiation doses customarily deemed safe on the basis of past experience have now, when combined with other modalities, led to severe late effects in different vital organs. The previously de? ned radiation tolerance dosages remain as valuable guides, but their applicability has changed signifi cantly. The emphasis is now placed on the volume of the organ irradiated, as well as the dose being used. New constructs rel- ing global (whole organ) and focal (partial volume) injury as a function of the dose volume histogram emerge as a signifi cant predictor of late effects on normal tissues. There are now mathematical models such as the model on standard dose, time–dose factors, and accumulated radiation effects that have been supplanted by linear-q- dratic equations using the alpha/beta ratio and its clinical applicability to normal tissue complications. This volume presents contemporary data relating to late effects on normal tissues.

Product Details

ISBN-13:	9783642080326
Publisher:	Springer Berlin Heidelberg
Publication date:	11/29/2010
Series:	Medical Radiology
Edition description:	Softcover reprint of hardcover 1st ed. 2008
Pages:	140
Product dimensions:	7.60(w) x 10.63(h) x 0.01(d)

Table of Contents

Radiation (and Medical) Biosurveillance.- Medical Countermeasures to Radiation Injury.- Ionizing Radiation and the Endothelium.- Inflammation and Cell Adhesion Molecules are Involved in Radiation-Induced Lung Injury.- Volume Effects in Radiation Damage to Rat Lung.- The Role of Imaging in the Study of Radiation-Induced Normal Tissue Injury.- Screening for Cardiovascular Disease in Survivors of Thoracic Radiation.- Hypoxia-Mediated Chronic Normal Tissue Injury.- Prevention and Treatment of Radiation Injuries.- Second Malignancies as a Consequence of Radiation Therapy.- Using Quality of Life Information to Rationally.- Cancer-Related Fatigue as a Late Effect:.- Normal Tissue TNM Toxicity Taxonomy.- Cancer Survivorship Research:.

Editorial Reviews

From the reviews:

"This book provides a basic science understanding of the processes behind the side effects of radiation. … is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. … The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. … Chapters outline the guidelines and models for researchers and clinicians … . should be in the library of every radiation oncology department." (Ann Pittier, Doody’s Review Service, August, 2008)

From the Publisher

Reviewer: Ann Pittier, MD (University of Washington Medical Center)
Description: With the tremendous success of cancer management, the goal of treatment has been to improve the therapeutic ratio in order to preserve an acceptable quality of life for patients who survive cancer. Treatments offered to preserve life are increasingly effective, but leave patients with life-long sequelae. This book provides those in the research and clinical setting a fundamental foundation upon which to build.
Purpose: The focus is on providing a molecular and physiologic understanding of the long-term side effects that often plague cancer survivors. This is particularly imperative as more patients are cured with modern medicine and radiation. To provide optimal care for these patients, a long term "chronic disease approach" must be employed, and researchers and clinicians alike must have a firm basis of understanding of the processes behind the side effects. Even with improvement of the therapeutic ratio this remains an important aspect of patient care and must be addressed in a multidisciplinary setting. This book provides a basic science understanding of the processes behind the side effects of radiation.
Audience: This book is appropriate for residents, clinicians, radiobiologists, and medical physicists as it addresses the fundamentals necessary for a firm understanding of radiation sequelae. It provides the framework for the knowledge that can be gained via scientific application or in a clinical setting.
Features: The color pictures, graphs, diagrams, and tables beautifully illustrate the main concepts of each chapter. Each chapter begins with a summary and is divided into clearly labeled segments. Chapters outline the guidelines and models for researchers and clinicians to use and address the in-depth physiologic and molecular background of radiation sequelae. This book is not meant to be a definitive text on diagnosis and management, but rather a platform upon which to build clinical/research knowledge.
Assessment: This fundamental look at long-term side effects of radiation should be in the library of every radiation oncology department. It details the current scientific understanding of the basis of side effects that are becoming increasingly important as more and more cancers are either cured or transitioned into "chronic disease" status.

Doody's Review Service