Current Practice of Gas Chromatography-Mass Spectrometry / Edition 1

by Wilfried M.A. Niessen

Overview

This volume details the principles and instrumentation of gas chromatography-mass spectrometry (CG-MS), and outlines industrial, environmental, pharmaceutical, clinical, toxicological, forensic and food-related applications, revealing findings from the laboratories of 40 contributing scientists around the world using GC-MS in practice. It describes upstream and downstream applications of GC-MS in the petroleum industry and identifies chlorinated compounds in the environment with quadrupole ion-trap technology and high-resolution sector instruments.

Product Details

ISBN-13:	9780367397425
Publisher:	Taylor & Francis
Publication date:	09/05/2019
Series:	Chromatographic Science , #86
Pages:	528
Product dimensions:	6.12(w) x 9.19(h) x (d)

About the Author

W. M. A. Niessen is the founder of hyphen MassSpec Consultancy, Leiden, The Netherlands, which provides consultation and training in analytical mass spectrometry in general, and LC-MS in particular. Formerly, he was a Faculty Member in the Division of Analytical Chemistry at the Leiden Amsterdam Center for Drug Research, Leiden University, The Netherlands. The author or coauthor of over 200 research papers, book chapters, and invited talks, including Liquid Chromatography-Mass Spectrometry, Second Edition (Marcel Dekker, Inc.), Dr. Niessen received the Ph.D. degree (1986) in analytical chemistry from the University of Amsterdam, The Netherlands.

Table of Contents

Preface iii

Contributors ix

Part I Principles and Instrumentation of Gas Chromatography-Mass Spectrometry

1 Principles and Instrumentation of Gas Chromatography-Mass Spectrometry W. M. A. Niessen 1

2 Principles and Applications of Surface Ionization in Gas Chromatography-Mass Spectrometry Toshihiro Fujii 31

Part II Industrial and Environmental Applications

3 Gas Chromatography-Mass Spectrometry in the Petroleum Industry C. S. Hsu D. Drinkwater 55

4 Analysis of Dioxins and Polychlorinated Biphenyls by Quadrupole Ion-Trap Gas Chromatography-Mass Spectrometry J. B. Plomley M. Lauševic R. E. March 95

5 Gas Chromatography-Mass Spectrometry Analysis of Chlorinated Organic Compounds M. T. Galceran F. J. Santos 117

6 On-Line Solid-Phase Extraction-Capillary Gas Chromatography-Mass Spectrometry for Water Analysis Thomas Hankemeier Udo A. Th. Brinkman 155

7 Gas Chromatography-Mass Spectrometry in Occupational and Environmental Health Risk Assessment with Some Applications Related to Environmental and Biological Monitoring of 1-Nitropyrene P. T. J. Scheepers R. Anzion R. P. Bos 199

8 Application of Solid-Phase Microextraction-Gas Chromatography-Mass Spectrometry in Quantitative Bioanalysis Paola Manini Roberta Andreoli 229

Part III Pharmaceutical and Clinical Applications

9 Gas Chromatography-Mass Spectrometry of Drugs in Biological Fluids After Automated Sample Pretreatment M. Valcárcel M. Gallego S. Cárdenas 247

10 Gas Chromatography-Mass Spectrometry Analysis of Anesthetics and Metabolites Using Multidimensional Detection Strategies M. Désage J. Guitton 267

11 Gas Chromatography-Mass Spectrometry in Clinical Stable Isotope Studies: Possibilities and Limitations F. Stellaard 285

12 Clinical Steroid Analysis by Gas Chromatography-Mass Spectrometry Stefan A. Wudy Janos Homoki Walter M. Teller 309

13 Gas Chromatography-Mass Spectrometry for Selective Screening for Inborn Errors of Metabolism Jörn Oliver Sass Adrian C. Sewell 341

Part IV Toxicological and Forensic Applications

14 Applications of Gas Chromatography-Mass Spectrometry in Clinical and Forensic Toxicology and Doping Control Hans H. Maurer 355

15 Detection of Drugs of Abuse by Gas Chromatography-Mass Spectrometry Jennifer S. Brodbelt Michelle Reyzer Mary Satterfield 369

16 Gas Chromatography-Mass Spectrometry Analysis of Explosives Shmuel Zitrin 387

Part V Food-Related Applications

17 Gas Chromatography-Mass Spectrometry Analysis of Flavors and Fragrances M. Careri A. Mangia 409

18 Gas Chromatography-Mass Spectrometry for Residue Analysis: Some Basic Concepts H. F. De Brabander K. De Wasch S. Impens R. Schilt M. S. Leloux 441

19 Applications of Gas Chromatography-Mass Spectrometry in Residue Analysis of Veterinary Hormonal Substances and Endocrine Disruptors R. Schilt K. De Wasch S. Impens H. F. De Brabander M. S. Leloux 455

20 Identification of Terpenes by Gas Chromatography-Mass Spectrometry A. Orav 483

Appendix 495

Index 499