Cytochrome Oxidase in Neuronal Metabolism and Alzheimer's Disease / Edition 1

by Francisco Gonzalez-Lima

Overview

This book is based on an international symposium titled "Cyhrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cyhrome oxidase histo­ chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break­ through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map­ ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized techniques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cyhrome oxidase cyhemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cyhrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re­ sulting in failure of oxidative energy metabolism. Could impairment of cyhrome oxi­ dase in energy metabolism initiate the degenerative process? Cyhrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegeneration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.

Product Details

ISBN-13:	9780306460241
Publisher:	Springer US
Publication date:	09/30/1998
Series:	Aging
Edition description:	1998
Pages:	290
Product dimensions:	6.10(w) x 9.25(h) x (d)

Table of Contents

I: Neuronal Metabolism and Cyhrome Oxidase Function.- 1. Brain Cyhrome Oxidase: Functional Significance and Bigenomic Regulation in the CNS.- 2. Quantitative Hishemistry of Cyhrome Oxidase Activity: Theory, Methods, and Regional Brain Vulnerability.- 3. Cyhrome Oxidase and Neuroanatomical Patterns: What Is the Connection?.- 4. Functional Mapping of Learning-Related Metabolic Activity with Quantitative Cyhrome Oxidase Hishemistry.- 5. Functional Imaging Probes to Study the Neural Bases of Behavior in Genetic Animal Models of ADHD: A Comparative Analysis of Short and Long-Term Markers of Neuronal Activity.- II: Alzheimer’s Disease and Cyhrome Oxidase Dysfunction.- 6. Cyhrome Oxidase Inhibition in Alzheimer’s Disease.- 7. Molecular Mechanisms of Impaired Mihondrial Gene Expression in Alzheimer’s Disease.- 8. Behavioral, Electrophysiological, and Biochemical Consequences of Chronic Cyhrome Oxidase Inhibition in Rats.- 9. Cyhrome Oxidase: A Predictive Marker of Neurodegeneration.- III: Appendix.- 10. Cyhrome Oxidase Atlas of Rat Brain.- Contributors.

Editorial Reviews

As a satellite to the 27th meeting of the Society for Neuroscience held October 28 in New Orleans, this symposium was dedicated to Dr. Margaret T.T. Wong-Reiley, developer of the method of cytochrome oxidase histochemical mapping of metabolism in the brain, on the 20th anniversary of this breakthrough. In this first ever compilation of papers applying this technique to the study of Alzheimer's, the 22 contributors--including Dr. Wong-Reiley--overview the role of cytochrome oxidase in cellular energy metabolism and neuronal activity and the methodology for its study via specific application examples. Part II treats the hypothesis that cytochrome inhibition may predict potential neurodegeneration, through discussions of animal models and genetic vulnerability of regions of the brain. Annotation c. by Book News, Inc., Portland, Or.

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