Cytokines and Autoimmune Diseases / Edition 1

by Vijay K. Kuchroo, Nora Sarvetnick, David A. Hafler, Lindsay B. Nicholson

Overview

Leading researchers synthesize scattered experimental data to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune diseases, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis. Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.

Product Details

ISBN-13:	9780896038561
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/09/2001
Edition description:	2002
Pages:	422
Product dimensions:	0.00(w) x 0.00(h) x 0.04(d)

About the Author

Kuchroo, Vijay K., DVM, PhD; Sarvetnick, Nora, PhD; Hafler, David A., MD; Nicholson, Lindsay B., PhD, MB

Table of Contents

I: Cytokines: Induction and Regulation.- 1 Transcriptional Regulation of Cytokine Gene Expression in Th Subsets.- 2 Chromatin Remodeling and Transcriptional Regulation of Cytokine Gene Expression in T Cells.- 3 Variant Ligands, Altered T Cell Receptor Signaling, Hierarchial Response Thresholds, and CD4+ Effector Responses.- 4 The Role of Costimulation in T Cell Differentiation.- 5 CD I d-Restricted NK T Cells and Autoimmunity.- 6 Role of T Cell Death and Cytokines in Autoimmunity.- 7 Role of Chemokines and Their Receptors in the Induction and Regulation of Autoimmune Disease.- II: Cytokines: Role in Specific Autoimmune Diseases.- 8 Cytokines and Resistance to Organ Specific Autoimmune Disease.- 9 The Role of Cytokines in Induction and Regulation of Autoimmune Uveitis.- 10 Pathogenic and Regulatory Cytokines in Experimental Autoimmune Encephalomyelitis.- 11 Role of Cytokines in Multiple Sclerosis and in Mucosal Tolerance.- 12 Cytokines and Human Type 1 Diabetes.- 13 Cytokines in Human Rheumatoid Arthritis and Murine Models.- 14 Systemic Lupus Erythematosus.- 15 Myasthenia Gravis.- III: Cytokines and Autoimmunity: A Synthesis.- 16 Cytokines in Autoimmune Disease.

Editorial Reviews

"Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease." -Immunology News

From the Publisher