Dermal Absorption and Decontamination: A Comprehensive Guide

by Aileen M. Feschuk (Editor), Rebecca M. Law (Editor), Howard I. Maibach (Editor)

Overview

This book is a comprehensive volume dedicated to dermal absorption and decontamination. Given risks including chemical warfare and accidents with toxic industrial chemicals, studies involving dermal absorption and decontamination are of the utmost importance. Each chapter consists of a systematic review on an important dermal absorption and/or decontamination topic. Chapters address key issues such as the general acceptance of water/ soap and water as the gold standard of dermal decontamination despite the fact that it commonly provides incomplete decontamination and may even result in a “wash-in effect” (an increased penetration of contaminant). Decontamination with other substances (e.g. RSDL) is explored, and factors that affect dermal penetration (e.g. anatomical variation) are summarized. All systematic reviews are comprehensive and up-to-date.

Dermal Absorption and Decontamination will be useful for many fields and disciplines. Firstly, information on dermal decontamination may be used by governments for military and national defense purposes in the event of chemical warfare. Additionally, this information would be of use to many production companies, whose employees are at risk of an accident with toxic industrial chemicals. Topics covered in the book will also be of use to pharmaceutical companies, especially those exploring transdermal delivery of drugs and is of great relevance to those in the medical field, particularly dermatologists.

Product Details

ISBN-13:	9783031092244
Publisher:	Springer International Publishing
Publication date:	10/06/2022
Edition description:	1st ed. 2022
Pages:	339
Product dimensions:	6.10(w) x 9.25(h) x (d)

About the Author

Aileen M Feschuk
Faculty of Medicine, Memorial University of Newfoundland, St. John’s, NL, Canada

Rebecca M Law, PharmD
School of Pharmacy, Memorial University of NewfoundlandFaculty of Medicine, Memorial University of Newfoundland
St. John’s, NL, Canada

Howard I Maibach, MD
Department of Dermatology, University of California San Francisco, San Francisco, CA, USA

Table of Contents

Written:

1. Efficacy of Water Based Skin Decontamination Using In Vivo Animal Models: A Systematic Review (Anuk Burli, Nadia Kashetsky, Aileen Feschuk, Rebecca. Law, Howard Maibach)
2. Efficacy of Water-Only or Soap and Water Skin Decontamination of Chemical Warfare Agents or Simulants Using In Vitro Human Models: A Systematic Review. (Chavy Chiang, Nadia Kashetsky, Aileen Feschuk, Anuk Burli, Rebecca Law, Howard Maibach)
3. Efficacy of Water Based Skin Decontamination of Occupational Chemicals Using In Vitro Human Skin Models: A Systematic Review. (Chavy Chiang, Nadia Kashetsky, Aileen Feschuk, Anuk Burli, Rebecca Law, Howard Maibach)
4. Efficacy of Water Based Skin Decontamination in In Vitro Animal Models (Maxwell Green, Nadia Kashetsky, Aileen Feschuk, Howard Maibach)
5. Comparative Efficacy of RSDL: A Systematic Review (Aileen Feschuk, Rebecca Law, Howard Maibach)
6. Regional Variation in Percutaneous Absorption Using In Vitro Human Models: A Systematic Review. (Aileen Feschuk, Nadia Kashetsky, Chavy Chiang, Anuk Burli, Halie Burdick, Rebecca Law, Howard Maibach)
7. Regional Variation in Cutaneous Blood Flow in Healthy Patients: A Systematic Review (Halie Burdick, Rebecca Law, Howard Maibach (Aileen Feschuk, Nadia Kashetsky, Anuk Burli, Chavy Chiang (order undetermined))

To be written:

1) Regional variation in trans-epidermal water loss
2) Regional variation in eccrine sweat
3) Regional variation in apocrine sweat
4) Regional variation in “other” physical properties
5) Regional variation in irritation syndrome (irritant dermatitis)
6) Regional Variation in allergic contact dermatitis
7) Regional variation in dermal cytokines and chemokines
8) Regional variation in dermal biochemistry
9) Regional variation in dermal electrolytes
10) Regional variation in hair follicles
11) Regional variation in aberrant apocrine glands
12) Regional variation in dermal glucose levels

Editorial Reviews

Reviewer: Patricia Wong, MD (Private Practice)
Description: This book addresses dermal absorption and decontamination. Research scientists who formulate methods to treat contaminated skin are aware of the multitude of variables involved in designing animal models to predict how human skin will react and extrapolating such knowledge to rapid chemical neutralization. For example, transepidermal water loss varies with age of the skin and body region. The chemical, its characteristics, absorption coefficient, time of application, amount applied, and spreadability measurements all affect the amount of damage that develops, and these same factors must be taken into account when designing the antidote.
Purpose: The purpose of this book is to inform scientists of the variables involved in creating substances to quickly and safely decontaminate the skin before significant dermal absorption occurs and causes harm. One of the goals is to serve as a reference guide for scientists involved in countering chemical warfare agents.
Audience: Scientists devoted to neutralizing and treating toxic chemicals, either from accidents or weapons, will likely be interested in reading this book, which is very basic science oriented.
Features: The book discusses the specialized instruments needed to properly evaluate the efficacy of a decontamination approach and to standardize measurements in the skin in order to evaluate the treatment responses. Some of the tools needed to execute these studies include liquid chromatography, mass spectrometry, laser Doppler imaging, infrared thermography, and radioactive markers to measure absorption.
Assessment: A well-equipped, state-of-the-art biochemistry laboratory in a large academic center or a well-funded private industry setting would be best suited for the explorations described in this book.

Doody's Review Service