Dermatological and Transdermal Formulations / Edition 1

by Kenneth A. Walters

Overview

Containing 350 illustrations, tables, and equations and covering AAPS/FDA guidelines for the experimentation and analysis of in vivo and in vitro percutaneous absorption, this reference provides comprehensive coverage of the development, preparation, and application of topical and transdermal therapeutic systems. Recognized international experts discuss the bioequivalence of dermatological and transdermal dosage forms. They explore the biochemistry and treatment of skin diseases, the structure and function of the skin, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation.

Product Details

ISBN-13:	9780367396343
Publisher:	CRC Press
Publication date:	10/17/2019
Pages:	592
Product dimensions:	7.00(w) x 10.00(h) x (d)

Table of Contents

The structure and function of the skin; common skin disorders and their topical treatment; basic mathematical principles in skin permeation; skin transport; methods for studying percutaneous absorption; formulation strategies for modulating skinpermeation; formulation and development of dermatological dosage forms; bioequivalence of dermal and transdermal formulations; scale-up of dermatological dosage forms; a case for multivariate optimization and product homogeneity; transdermal drug deliverysystems; safety considerations for dermal and transdermal products; transdermal delivery and cutaneous reactions.

Editorial Reviews

The latest advances in the development, preparation, and application of topical and transdermal therapeutic systems are reviewed in this work, and detailed background is given on the structure and function of the skin as well as the biochemistry and treatment of various skin diseases, adverse dermal responses to drug formulations, mechanisms of drug transport through barrier membranes, and methods for measuring and modulating percutaneous permeation. Specific subjects include basic mathematical principles in skin permeation, bioavailability and bioequivalence of dermatological formulations, and safety considerations for dermal and transdermal formulations. Contributors work in fields including dermatology, skin toxicity testing, medicine, and pharmaceutical sciences. Walters is the author or coauthor of some 100 peer-reviewed articles and coeditor of two other books on skin penetration and dermal absorption. Annotation c. Book News, Inc., Portland, OR (booknews.com)

"…a comprehensive overview….gathers the immense amount of information available on skin…in a very stepwise and clear way."
-Pharmazie

"…useful addition to the literature…an impressive and authorative work. It is well laid out and easy on the eye, many clear diagrams and figures illustrate the text…a worthy reference work…should be on the bookshelf of everyone interested in this field."
-ISSX Newsletter



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