Detection of Drugs and Their Metabolites in Oral Fluid

by Robert M. White, Christine M. Moore

Overview

Detection of Drugs and Their Metabolites in Oral Fluid presents the analytical chemistry methods used for the detection and quantification of drugs and their metabolites in human oral fluid. The authors summarize the state of the science, including its strengths, weaknesses, unmet methodological needs, and cutting-edge trends. This volume covers the salient aspects of oral fluid drug testing, including specimen collection and handling, initial testing, point of collection testing (POCT), specimen validity testing (SVT), and confirmatory and proficiency testing. Analytes discussed include amphetamines, cannabinoids, cocaine, opiates, phencyclidine, cannabimimetics, and miscellaneous drugs.

This practical guide helps users turn knowledge into practice, moving logically from an outline of the problem, to the evaluation of the appropriateness of oral fluid as a test medium, and finally to a consideration of detection methods and their validation and employment.

Product Details

ISBN-13:	9780128145951
Publisher:	Elsevier Science
Publication date:	02/27/2018
Series:	Emerging Issues in Analytical Chemistry
Pages:	140
Product dimensions:	6.00(w) x 9.00(h) x (d)

About the Author

Dr. Robert M. White, Sr., retired in 2017 from his position as Senior Forensic Scientist at the Center for Forensic Sciences, RTI International, Research Triangle Park, NC, USA, and is currently the Registered Agent for RMW Consulting, Inc., Naples, FL. He has extensive experience in risk assessment, legal consulting, and federal and College of American Pathologists (CAP) inspections. Dr. White also has significant experience with conducting forensic and clinical drug testing.

Dr. Christine M. Moore, PhD, DSc, is the Chief Toxicologist, Research for Immunalysis (a part of Abbott), Pomona, CA. She holds a PhD in Forensic Toxicology from the University of Glasgow, Scotland (1989). She is Board Certified in Toxicological Chemistry by the American Board of Clinical Chemistry (DABCC), and is a Fellow of the Royal Society of Chemistry and the American Academy of Forensic Sciences. Dr. Moore is Past President of both the Society of Forensic Toxicologists (SOFT) and the Society of Hair Testing. She is a member of the International Association of Toxicologists (TIAFT), the American Association of Clinical Chemistry (AACC), the Research Society on Alcoholism (RSA), the California Association of Toxicologists (CAT), and the International Council on Alcohol, Drugs and Traffic Safety (ICADTS). Additionally, she is Past-President of the Mid-West Association for Toxicology and Therapeutic Drug Monitoring (MATT) and is past Chair of the Toxicology Section of the American Academy of Forensic Sciences. She serves on the Editorial Board of the Journal of Analytical Toxicology and is a reviewer for several other journals. She has published extensively on the analysis of drugs in biological matrices, including oral fluid, blood, meconium, and hair.

Table of Contents

1. Introduction2. Oral Fluid Pharmacokinetics3. Collection of Oral Fluid4. Point of Collection Testing5. Initial Testing 6. Specimen Validity Testing (SVT) 7. Confirmatory Testing 8. Proficiency Testing9. Individual Analytes, Specimen Handling, Stability, and Other Issues10. Concluding Remarks

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From the Publisher

An up-to-date guide on the methods involved in oral fluid analysis for pharmaceutical detection