DNA Repair in Cancer Therapy / Edition 1

by Lawrence C. Panasci, Moulay A. Alaoui-Jamali

Overview

A comprehensive review of the recent developments in DNA repair that have potential for translational and clinical applications. The authors explain in detail the various mechanisms by which cancer cells can circumvent anticancer therapy and limits its usefulness in patients. They also review the clinical impact of such novel inhibitors of DNA repair mechanisms as methylguanine-DNA-methyltransferase. Also examined are inhibitors of other DNA repair enzymes such as PARP and DNA-PK, now under development and close to clinical trials. The book captures-for both cancer researchers and practicing oncologists dealing with hallmark "relapse" or "drug resistance" phenomena on a daily basis-the many exciting new uses of DNA repair inhibitors, either alone or in combination with anticancer therapies.

Product Details

ISBN-13:	9781617374807
Publisher:	Springer-Verlag New York, LLC
Publication date:	11/19/2010
Series:	Cancer Drug Discovery and Development
Edition description:	Softcover reprint of hardcover 1st ed. 2004
Pages:	363
Product dimensions:	5.98(w) x 9.02(h) x 0.35(d)

Table of Contents

Content.- 1 Clinical Resistance to Alkylators: Status and Perspective.- 2 Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard and DNA Crosslinking Agents.- 3 Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs.- 4 Chemosensitization to Platinum-Based Anticancer Drugs: Current Trends and Future Prospects.- 5 Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumor Cells.- 6 Stress-Activated Signal Transduction Pathways in DNA Damage Response: Implications for Repair, Arrest, and Therapeutic Interventions.- 7 Overcoming Resistance to Alkylating Agents by Inhibitors of O6-Alkylguanine-DNA Alkyltransferase.- 8 Cellular Protection Against the Antitumor Drug Bleomycin.- 9 Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death.- 10 Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy.- 11 Strand-Break Repair and Radiation Resistance.- 12 V(D)J Recombination and DNA Double-Strand-Break Repair: From Immune Deficiency to Tumorigenesis.- 13 Inherited Disorders of Genomic Instability and Cancer Susceptibility.- 14 Role of BRCA1 and BRCA2 in DNA Repair and Potential Impact on Therapeutics.- 15 Genetic Variations in DNA Repair: Their Implications in Human Cancer Risk, Prevention, and Therapy.

Editorial Reviews

4 Stars! from Doody

Reviewer: Victor V. Levenson, MD, PhD (Northwestern University Feinberg School of Medicine)
Description: This book describes the modern state of the field of DNA repair — both enzymology and signal transduction — as it relates to cancer therapy, including chemotherapy and radiotherapy. The book also has several chapters on mechanisms of resistance to therapy and means of elucidation and reversing this resistance.
Purpose: The main goal of the book is to bridge the gap between clinical phenomena of drug resistance and the current state-of-the art knowledge in the field, and to review the latest developments in the field pertinent for translational and clinical use. There is an obvious need for a comprehensive review of DNA repair as applied to cancer therapy and emergence of resistance, and this book is definitely appropriate and timely.
Audience: The intended audience includes physicians, pharmacologists, and medical and basic researchers at different levels of their training. Each group will find certain sections that are more relevant to their specific subspecialty, which is expected for such a broad and complex field as drug interactions with cellular DNA. At the same time, the book provides a well written overview of related areas assembled in one volume.
Features: The book contains 15 chapters written by different authors, and can be divided into four main areas: DNA repair and drug resistance to alkylating drugs; DNA repair of double-stranded breaks and cellular resistance to radiation; cellular responses to DNA damage and their involvement in resistance to therapy; and genomic instability and genetic variations as determinants of cancer susceptibility. The book gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field. It could also serve as a handy reference if the index was not so small and unbalanced (e.g. no entries for a topic that is discussed in the vast majority of chapters).
Assessment: The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. Moreover, no similar reviews have been published recently, so the need for such a book is fairly obvious.

Doody's Review Service

...gives a comprehensive review of the modern status of the DNA repair field for cancer researchers and clinical practitioners and provides a solid basis for in-depth study of different areas in this field...The book is a timely publication with a significant intended audience that will be served well. The book is well planned, well written, comprehensive, and addresses recent findings in the field. -Doody's Health Sciences Book Review Journal

"...extensive and extremely detailed...a comprehensive review of DNA repair." - The Annals of Pharmacotherapy

"Comprehensive and cutting-edge, for both cancer researchers and practicing oncologists dealing with the hallmark 'relapse; or 'drug resistance' phenomena on a daily basis...." Tumori

From the Publisher